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Centre for Cellular and Molecular Biology Wiki2Web Clarity Challenge

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Study Guide: Centre for Cellular and Molecular Biology (CCMB): An Overview

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Centre for Cellular and Molecular Biology (CCMB): An Overview Study Guide

Founding, Governance, and Institutional Identity

The Centre for Cellular and Molecular Biology (CCMB) is situated in Mumbai, India.

Answer: False

Explanation: The Centre for Cellular and Molecular Biology (CCMB) is located in Hyderabad, India, not Mumbai.

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CCMB operates under the Council of Scientific and Industrial Research (CSIR).

Answer: True

Explanation: The Centre for Cellular and Molecular Biology (CCMB) functions as an autonomous government body under the aegis of the Council of Scientific and Industrial Research (CSIR).

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CCMB was established on April 1, 1981.

Answer: False

Explanation: The Centre for Cellular and Molecular Biology (CCMB) was officially established on April 1, 1977.

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Dr. P. M. Bhargava was the first director of CCMB.

Answer: True

Explanation: Dr. P. M. Bhargava served as the inaugural director of the Centre for Cellular and Molecular Biology (CCMB).

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CCMB has been recognized as a Centre of Excellence by the Third World Academy of Sciences (TWAS).

Answer: True

Explanation: CCMB holds international recognition as a Centre of Excellence, including designation by the Third World Academy of Sciences (TWAS).

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CCMB scientists have received multiple Shanti Swarup Bhatnagar awards.

Answer: True

Explanation: Scientists affiliated with CCMB have been recipients of multiple prestigious awards, including numerous Shanti Swarup Bhatnagar awards.

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The main CCMB campus is located near the Habsiguda metro station.

Answer: True

Explanation: The primary campus of CCMB is situated on the inner ring road of Hyderabad and is accessible via public transport, including the Hyderabad metro system with a station at Habsiguda.

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CCMB was initially established as a full-fledged national laboratory.

Answer: False

Explanation: CCMB was initially established as a semi-autonomous Centre and later achieved the status of a full-fledged national laboratory during the period of 1981-82.

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CCMB has received the CSIR Technology Award multiple times.

Answer: True

Explanation: CCMB has been honored with the CSIR Technology Award on multiple occasions for its technological contributions.

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What is the full name of the research institute abbreviated as CCMB, located in Hyderabad?

Answer: Centre for Cellular and Molecular Biology

Explanation: The full designation of the research institute abbreviated as CCMB is the Centre for Cellular and Molecular Biology.

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Under which autonomous government body does CCMB operate?

Answer: Council of Scientific and Industrial Research (CSIR)

Explanation: CCMB operates as an autonomous government body under the purview of the Council of Scientific and Industrial Research (CSIR).

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What international recognition has CCMB received from UNESCO-associated networks?

Answer: Centre of Excellence

Explanation: CCMB has been recognized as a 'Centre of Excellence' by UNESCO-associated networks, signifying its high standing in molecular and cell biology research and training.

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When was the Centre for Cellular and Molecular Biology (CCMB) officially established?

Answer: April 1, 1977

Explanation: The Centre for Cellular and Molecular Biology (CCMB) was officially established on April 1, 1977.

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Besides UNESCO, CCMB has been recognized by which other international body as a Centre of Excellence for Research and Training?

Answer: The World Academy of Sciences (TWAS)

Explanation: CCMB holds international recognition as a Centre of Excellence, including designation by the Third World Academy of Sciences (TWAS).

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Which prestigious award has CCMB received multiple times for its scientific and technological achievements?

Answer: The CSIR Technology Award

Explanation: CCMB has been honored with the CSIR Technology Award on multiple occasions for its significant scientific and technological achievements.

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What is the status of CCMB within the Council of Scientific and Industrial Research (CSIR)?

Answer: An autonomous government body

Explanation: CCMB functions as an autonomous government body operating under the Council of Scientific and Industrial Research (CSIR).

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Research Scope and Key Areas

CCMB's research programs are solely focused on basic research in modern biology.

Answer: False

Explanation: CCMB's research portfolio encompasses high-quality basic research, research relevant to societal needs, and application-oriented research towards commercialization, not solely basic research.

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Neurobiology and bioinformatics are among the research areas investigated at CCMB.

Answer: True

Explanation: Neurobiology and bioinformatics are indeed among the diverse research areas pursued at the Centre for Cellular and Molecular Biology (CCMB).

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CCMB's research on antimicrobial peptides is depicted in associated image captions.

Answer: True

Explanation: The presence of image captions related to 'Work on antimicrobial peptides at CCMB' indicates that research in this area is conducted and potentially visually represented by the institution.

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Which of the following is NOT one of the major categories of research programs at CCMB?

Answer: Research focused on astrophysics and cosmology

Explanation: Astrophysics and cosmology are not among the major categories of research programs conducted at CCMB, which instead focus on frontier areas of modern biology, societal needs, and commercialization.

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Which specific research area, related to developmental processes, is investigated at CCMB?

Answer: Evolution & Development

Explanation: Evolution & Development (Evo-Devo) is a key research area investigated at CCMB, focusing on the developmental processes within biological systems.

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Which of the following is a key research area within modern biology investigated at CCMB?

Answer: Membrane Biology

Explanation: Membrane Biology is identified as a key research area within modern biology investigated at the Centre for Cellular and Molecular Biology (CCMB).

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Technological Innovations and Discoveries

India was the first country in the world to develop its own DNA fingerprinting technology, thanks to CCMB.

Answer: False

Explanation: India was the third country in the world to develop its own DNA fingerprinting technology, following the work done at CCMB.

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CCMB's universal primer technology can identify the species of origin for any animal product.

Answer: True

Explanation: CCMB's developed universal primer technology possesses the capability to ascertain the species of origin from any animal product, proving valuable in forensic and regulatory contexts.

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A specific heart disease mutation identified by CCMB affects only a small number of people in India.

Answer: False

Explanation: A specific heart disease mutation identified by CCMB affects a substantial portion of the Indian population, estimated at approximately 60 million individuals.

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CCMB developed the first gene knockout mouse in India.

Answer: True

Explanation: CCMB achieved a significant milestone by developing the first genetically engineered, gene knockout mouse within India.

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CCMB developed a program for screening and validating anti-cancer drugs.

Answer: True

Explanation: CCMB established a systematic program dedicated to the screening and validation of anti-cancer drugs, thereby advancing cancer treatment research and development.

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Genomic studies by CCMB have shown the Indian population to be genetically identical to European populations.

Answer: False

Explanation: Genomic studies conducted by CCMB have revealed the distinct genetic profile of the Indian population, rather than showing it to be identical to European populations.

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CCMB developed a commercially available diagnostic kit for detecting tuberculosis.

Answer: False

Explanation: CCMB has developed and commercialized a diagnostic kit based on recombinant DNA technology, but it is for ophthalmic infections, not tuberculosis.

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The Improved Samba Mahsuri rice strain is resistant to Bacterial Leaf Blight (BLB).

Answer: True

Explanation: The Improved Samba Mahsuri rice strain, developed by CCMB, exhibits resistance to Bacterial Leaf Blight (BLB), offering significant benefits to agricultural productivity.

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CCMB discovered that microsatellites in non-coding DNA have no known function.

Answer: False

Explanation: CCMB's research revealed that microsatellites within non-coding DNA possess known functions, contributing to a more nuanced understanding of genetic regulation.

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CCMB identified the gene CPA1 as responsible for Alzheimer's disease.

Answer: False

Explanation: CCMB identified the CPA1 gene, but it is associated with chronic pancreatitis, not Alzheimer's disease.

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CCMB is working on developing lab-grown meat for sustainable food production.

Answer: True

Explanation: CCMB is actively engaged in research and development concerning lab-grown meat as part of its exploration into sustainable food production methodologies.

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CCMB scientists discovered a gene linked to chronic pancreatitis.

Answer: True

Explanation: CCMB scientists have identified a gene linked to chronic pancreatitis, specifically the CPA1 gene.

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What significant technological achievement did CCMB develop in India related to DNA analysis, and what was its global standing?

Answer: DNA Fingerprinting Technology

Explanation: CCMB developed the DNA Fingerprinting Technology in India, making India the third country globally to possess this capability.

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The universal primer technology developed by CCMB is useful for what purpose?

Answer: Identifying the species of origin from animal products

Explanation: CCMB's universal primer technology is useful for identifying the species of origin from any animal product.

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What pioneering work in genetic engineering was achieved by CCMB with the development of a gene knockout mouse in India?

Answer: Creation of the first genetically engineered, gene knockout mouse

Explanation: CCMB achieved a pioneering feat in genetic engineering by developing the first genetically engineered, gene knockout mouse in India.

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What contribution did CCMB make regarding anti-cancer drug development?

Answer: Developed a systematic screening and validation program

Explanation: CCMB established a systematic program dedicated to the screening and validation of anti-cancer drugs, thereby advancing cancer treatment research and development.

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CCMB's genomic studies have revealed what about the Indian population?

Answer: It is genetically unique.

Explanation: Genomic studies conducted by CCMB have revealed the distinct and unique genetic profile of the Indian population.

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What type of diagnostic kit has CCMB commercially delivered for detecting pathogens?

Answer: A kit for ophthalmic infections based on recombinant DNA technology

Explanation: CCMB has commercially delivered a diagnostic kit based on recombinant DNA technology designed for the detection of pathogens that cause ophthalmic infections.

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The Improved Samba Mahsuri rice strain, discovered by CCMB, offers farmers protection against which disease?

Answer: Bacterial Leaf Blight (BLB)

Explanation: The Improved Samba Mahsuri rice strain, developed by CCMB, exhibits resistance to Bacterial Leaf Blight (BLB), offering significant benefits to agricultural productivity.

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What functionality did CCMB discover regarding microsatellites in non-coding DNA?

Answer: They act as regulatory elements.

Explanation: CCMB's research revealed that microsatellites within non-coding DNA possess known functions, acting as regulatory elements and contributing to a more nuanced understanding of genetic structures.

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In collaboration with the Asian Institute of Gastroenterology, CCMB identified which gene associated with chronic pancreatitis?

Answer: CPA1

Explanation: CCMB, in collaboration with the Asian Institute of Gastroenterology, identified the CPA1 gene, which is associated with causing chronic pancreatitis.

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CCMB incubated Shantha Biotechnics, helping it develop what crucial product?

Answer: A recombinant vaccine against Hepatitis-B

Explanation: Through its incubation of Shantha Biotechnics, CCMB supported the development of a recombinant vaccine against Hepatitis-B, making it affordable for the Indian population.

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What is CCMB exploring in the field of sustainable food production?

Answer: Development of lab-grown meat

Explanation: CCMB is actively engaged in research and development concerning lab-grown meat as part of its exploration into sustainable food production methodologies.

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What is a significant outcome of CCMB's genomic studies concerning specific tribal groups?

Answer: Investigating their origins

Explanation: Through genomic studies, CCMB has investigated the origins of specific tribal groups, contributing to anthropological and genetic understanding.

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Specialized Centers, Incubators, and Facilities

LaCONES assists in identifying the source of smuggled animals.

Answer: True

Explanation: The Laboratory for the Conservation of Endangered Species (LaCONES) aids governmental efforts by tracing the sources of smuggled animals and contributing to wildlife conservation initiatives.

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The Innovation Hub (iHUB) at CCMB primarily focuses on developing agricultural technologies.

Answer: False

Explanation: The Innovation Hub (iHUB) at CCMB is dedicated to molecular diagnostics, wildlife forensics, and supporting life science startups, rather than agricultural technologies.

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AIC-CCMB supports early-stage life science startups.

Answer: True

Explanation: The Atal Incubation Centre-CCMB (AIC-CCMB) provides crucial support for early-stage life science startups.

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CCMB does not support startups involved in vaccine development.

Answer: False

Explanation: CCMB, through initiatives like AIC-CCMB, actively supports startups involved in vaccine development, among other life science sectors.

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CCMB demonstrated artificial insemination in elephants for conservation purposes.

Answer: False

Explanation: CCMB demonstrated artificial insemination for conservation purposes, but this was in spotted deer, not elephants.

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CCMB offers advanced instrumentation facilities only to its own researchers.

Answer: False

Explanation: CCMB extends access to its advanced instrumentation facilities to external researchers, making them available at reasonable costs to foster broader scientific inquiry.

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CCMB served as a COVID-19 testing center in Telangana during the pandemic.

Answer: True

Explanation: During the COVID-19 pandemic, CCMB played a role in Telangana by serving as a testing center for patient samples and contributing to the understanding of SARS-CoV-2 biology.

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The Medical Biotechnology Complex (iHUB) at CCMB supports early-stage life science startups.

Answer: True

Explanation: The Medical Biotechnology Complex, functioning as the Innovation Hub (iHUB) at CCMB, provides support for early-stage life science startups.

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What is the primary function of the Laboratory for the Conservation of Endangered Species (LaCONES)?

Answer: Conserving Indian wildlife using biological techniques

Explanation: The primary function of the Laboratory for the Conservation of Endangered Species (LaCONES) is to conserve Indian wildlife through the application of modern biological techniques and assisted reproductive technologies.

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How does LaCONES contribute to combating wildlife crime?

Answer: By identifying the source of smuggled animals

Explanation: LaCONES contributes to combating wildlife crime by assisting authorities in identifying the source of smuggled animals and tracing their origins.

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What is a key service offered by the Medical Biotechnology Complex (Innovation Hub/iHUB) at CCMB?

Answer: Performing molecular diagnostic tests for genetic disorders

Explanation: A key service offered by the Medical Biotechnology Complex (Innovation Hub/iHUB) at CCMB includes performing molecular diagnostic tests for genetic disorders.

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Which initiative, backed by NITI Aayog, supports early-stage life science startups within CCMB's Innovation Hub?

Answer: Atal Incubation Centre-CCMB (AIC-CCMB)

Explanation: The Atal Incubation Centre-CCMB (AIC-CCMB), supported by NITI Aayog, functions within CCMB's Innovation Hub to foster early-stage life science startups.

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CCMB supports startups in areas like drug discovery and vaccine development through which program?

Answer: Atal Incubation Centre-CCMB (AIC-CCMB)

Explanation: CCMB supports startups in critical areas such as drug discovery and vaccine development through its Atal Incubation Centre-CCMB (AIC-CCMB) program.

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CCMB demonstrated which reproductive technology for the conservation of spotted deer?

Answer: Artificial insemination

Explanation: CCMB demonstrated artificial insemination for conservation purposes, specifically in spotted deer.

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During the COVID-19 pandemic, CCMB played which role in Telangana?

Answer: Serving as a testing center for patient samples

Explanation: During the COVID-19 pandemic, CCMB played a role in Telangana by serving as a testing center for patient samples and contributing to the understanding of SARS-CoV-2 biology.

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How does CCMB facilitate the use of its advanced instrumentation facilities by the broader scientific community?

Answer: By making them available to external users at reasonable costs

Explanation: CCMB facilitates broader scientific research by making its state-of-the-art instrumentation facilities available to external users at reasonable costs.

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Collaborations and Partnerships

CCMB collaborates with the Tata Institute of Fundamental Research (TIFR).

Answer: True

Explanation: CCMB maintains active collaborations with various national research institutions, including the Tata Institute of Fundamental Research (TIFR).

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CCMB receives funding for collaborative projects from the World Health Organization (WHO).

Answer: False

Explanation: While CCMB receives funding from various international institutions, the World Health Organization (WHO) is not listed as a source for its collaborative projects in the provided information.

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CCMB is collaborating with the University of Nebraska Medical Center on glaucoma research.

Answer: True

Explanation: CCMB is engaged in collaborative translational research with the University of Nebraska Medical Center, focusing specifically on glaucoma.

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Which of these national institutes is listed as a collaborator of CCMB?

Answer: Tata Institute of Fundamental Research (TIFR)

Explanation: The Tata Institute of Fundamental Research (TIFR) is listed among the national institutes with which CCMB actively collaborates.

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Which US-based institution is mentioned as a source of funding for CCMB's collaborative projects?

Answer: National Institutes of Health (NIH)

Explanation: The National Institutes of Health (NIH) in the United States is mentioned as one of the international institutions providing funding for CCMB's collaborative projects.

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CCMB is collaborating with the University of Nebraska Medical Center on research related to which medical condition?

Answer: Glaucoma

Explanation: CCMB is engaged in collaborative translational research with the University of Nebraska Medical Center, focusing specifically on glaucoma.

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Education, Training, and Impact

Admission to CCMB's PhD program requires only a written application test.

Answer: False

Explanation: Admission to CCMB's PhD program involves not only a written application test but also subsequent interviews.

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Students joining CCMB's PhD program typically need to secure their own fellowships.

Answer: True

Explanation: It is typical for students admitted to CCMB's doctoral program to secure their own fellowships from national funding agencies like CSIR, UGC, DBT, ICMR, or DST.

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Alumni of CCMB's PhD program exclusively pursue careers in academia.

Answer: False

Explanation: Alumni from CCMB's PhD program pursue careers predominantly in academia and the life science industry, both domestically and internationally, rather than exclusively in academia.

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CCMB played a role in establishing the Centre for DNA Fingerprinting and Diagnostics (CDFD).

Answer: True

Explanation: CCMB's foundational work and success with DNA fingerprinting technology were instrumental in the subsequent establishment of the Centre for DNA Fingerprinting and Diagnostics (CDFD).

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CCMB's DNA fingerprinting technology was accepted as evidence in the Indian judicial system before 1990.

Answer: False

Explanation: The provided information confirms that CCMB's DNA fingerprinting technology has been accepted and utilized within the Indian judicial system, but it does not specify whether this acceptance occurred prior to 1990.

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What is a prerequisite for admission into CCMB's PhD program, besides the application test?

Answer: Successful completion of subsequent interviews

Explanation: Beyond the written application test, successful completion of subsequent interviews is a prerequisite for admission into CCMB's PhD program.

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Which organizations are mentioned as typical sources for PhD student fellowships at CCMB?

Answer: CSIR, UGC, DBT, ICMR, or DST

Explanation: Typical sources for PhD student fellowships at CCMB include national agencies such as CSIR, UGC, DBT, ICMR, and DST.

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Where do most alumni of CCMB's PhD program pursue their careers?

Answer: Primarily in academia or the life science industry

Explanation: The majority of CCMB PhD program alumni pursue careers predominantly in academia or the life science industry, both within India and internationally.

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How have CCMB's students and scientists contributed to the growth of scientific institutions in India?

Answer: By training scientists who later founded or led institutes

Explanation: CCMB has significantly contributed to the establishment and leadership of numerous scientific and educational institutions across India through its alumni and former scientists.

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What role did CCMB play concerning the Centre for DNA Fingerprinting and Diagnostics (CDFD)?

Answer: It was instrumental in establishing CDFD.

Explanation: CCMB's foundational work and success with DNA fingerprinting technology were instrumental in the subsequent establishment of the Centre for DNA Fingerprinting and Diagnostics (CDFD).

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How has CCMB's DNA fingerprinting technology been applied to the Indian judicial system?

Answer: By providing critical evidence in criminal cases

Explanation: CCMB's DNA fingerprinting technology has significantly aided the Indian judicial system by providing critical evidence in numerous high-profile criminal cases, such as murders, assassinations, and rapes.

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What was a notable application of CCMB's DNA fingerprinting technology in 2000?

Answer: Identifying victims of the Singapore Airlines plane crash

Explanation: In the year 2000, CCMB's DNA fingerprinting technology was notably applied to identify victims of the Singapore Airlines plane crash.

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What is the societal benefit of CCMB's genetic disorder testing facilities?

Answer: They offer services at nominal rates, improving access to diagnostics

Explanation: CCMB's genetic disorder testing facilities provide a significant societal benefit by offering services at nominal rates, thereby enhancing access to diagnostic healthcare for patients in India and neighboring countries.

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How does CCMB contribute to training professionals in specific government sectors?

Answer: By providing specialized training on DNA technologies to forest and judiciary officials

Explanation: CCMB contributes to professional development by offering specialized training programs, particularly to forest and judiciary officials, focusing on the application of DNA technologies in their respective fields.

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The establishment of which institute in Hyderabad was influenced by CCMB's DNA fingerprinting success?

Answer: Centre for DNA Fingerprinting and Diagnostics (CDFD)

Explanation: CCMB's success with DNA fingerprinting technology was instrumental in influencing the establishment of the Centre for DNA Fingerprinting and Diagnostics (CDFD) in Hyderabad.

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