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Obstructive sleep apnea (OSA) is characterized by recurrent episodes of complete or partial upper airway obstruction during sleep, leading to reduced breathing, decreased blood oxygen saturation, or sleep disruption.
Answer: True
Explanation: Obstructive sleep apnea is defined by recurrent episodes of complete or partial upper airway obstruction during sleep, which results in reduced breathing, decreased blood oxygen saturation, or sleep disruption.
Episodes of partial reduction in breathing during sleep in OSA are termed 'apneas,' while complete cessation is termed 'hypopneas.'
Answer: False
Explanation: In OSA, episodes of complete or near-complete cessation of breathing are termed 'apneas,' while partial reductions in breathing are referred to as 'hypopneas.' The question reverses these definitions.
The terms 'obstructive sleep apnea syndrome' (OSAS) or 'obstructive sleep apnea-hypopnea syndrome' (OSAHS) are used when OSA is accompanied by noticeable daytime symptoms like excessive sleepiness.
Answer: True
Explanation: The terms OSAS or OSAHS are specifically applied when OSA presents with clinically significant daytime symptoms, such as excessive daytime sleepiness or cognitive impairment.
The International Classification of Sleep Disorders (ICSD-3) classifies obstructive sleep apnea into adult and pediatric categories, distinguishing it from central sleep apnea by the presence of continued inspiratory effort.
Answer: True
Explanation: The ICSD-3 classifies OSA into adult and pediatric categories and differentiates it from central sleep apnea by the presence of continued or increased inspiratory effort despite absent airflow.
The physiological mechanism of OSA involves an increase in upper-airway muscle tone during REM sleep, leading to obstruction.
Answer: False
Explanation: The physiological mechanism of OSA involves a *reduction* in upper-airway muscle tone during the transition from wakefulness to sleep, particularly during REM sleep, which leads to obstruction.
The prevalence of OSA in individuals aged 65 and older is estimated to be around 10-20%.
Answer: False
Explanation: The prevalence of OSA in individuals aged 65 and older was found to be as high as 84%, significantly higher than 10-20%.
Which of the following best characterizes Obstructive Sleep Apnea (OSA)?
Answer: Recurrent episodes of complete or partial upper airway obstruction during sleep.
Explanation: Obstructive Sleep Apnea (OSA) is primarily characterized by recurrent episodes of complete or partial upper airway obstruction during sleep.
In the context of OSA, what term is used for episodes of complete or near-complete cessation of breathing?
Answer: Apneas
Explanation: Episodes of complete or near-complete cessation of breathing in OSA are specifically termed 'apneas'.
When are the terms 'obstructive sleep apnea syndrome' (OSAS) or 'obstructive sleep apnea-hypopnea syndrome' (OSAHS) applied?
Answer: When OSA is accompanied by noticeable daytime symptoms like excessive sleepiness.
Explanation: The terms OSAS or OSAHS are used when OSA is associated with noticeable daytime symptoms, such as excessive sleepiness or cognitive impairment.
According to the ICSD-3, how is obstructive sleep apnea differentiated from central sleep apnea?
Answer: By the presence of continued or increased inspiratory effort despite absent airflow in obstructive sleep apnea.
Explanation: The ICSD-3 differentiates obstructive sleep apnea from central sleep apnea by the presence of continued or increased inspiratory effort despite absent airflow in OSA.
What is the underlying physiological mechanism of OSA during the transition from wakefulness to sleep?
Answer: A reduction in upper-airway muscle tone, particularly during REM sleep.
Explanation: The underlying physiological mechanism of OSA involves a reduction in upper-airway muscle tone during the transition from wakefulness to sleep, especially during REM sleep.
What was the estimated prevalence of OSA (at least 5 apnea events per hour) in the general adult population (18 and older) according to a recent meta-analysis?
Answer: 9% to 38%.
Explanation: A recent meta-analysis estimated the prevalence of OSA (at least 5 apnea events per hour) in the general adult population (18 and older) to be between 9% and 38%.
Transient episodes of OSA can be caused by upper respiratory infections, tonsillitis, or substances like alcohol that relax body tone.
Answer: True
Explanation: Upper respiratory infections, tonsillitis, and substances such as alcohol that induce muscle relaxation are known transient factors that can cause episodes of OSA.
Obesity is a minor risk factor for OSA, with only a slight increase in risk for severely obese individuals.
Answer: False
Explanation: Obesity is a major risk factor for OSA, with the risk for sleep apnea ranging between 55% and 90% in severely obese individuals.
In children, obstructive tonsils and adenoids are a common cause of OSA, and their surgical removal can sometimes cure the condition.
Answer: True
Explanation: Enlarged tonsils and adenoids are a common anatomical cause of OSA in children, and adenotonsillectomy can often resolve the condition.
Pulmonologists and neurologists often attribute OSA causes to structural features like enlarged tonsils, while otorhinolaryngologists focus on advanced age and decreased muscle tone.
Answer: False
Explanation: Pulmonologists and neurologists typically attribute OSA causes to advanced age and decreased muscle tone, whereas otorhinolaryngologists focus on structural features like enlarged tonsils or a floppy soft palate. The question reverses these perspectives.
Being male, post-menopausal status in women, and pregnancy are all considered risk factors for OSA.
Answer: True
Explanation: Male gender, post-menopausal status in women, and pregnancy are all recognized risk factors for OSA.
Genetic factors contribute to OSA susceptibility only through direct genetic contributions, not indirect phenotypes.
Answer: False
Explanation: Genetic factors contribute to OSA susceptibility through both direct genetic contributions and indirect contributions via 'intermediate' phenotypes such as craniofacial structure.
Down syndrome and Pierre Robin sequence are examples of craniofacial syndromes that can predispose individuals to OSA.
Answer: True
Explanation: Down syndrome and Pierre Robin sequence are indeed craniofacial syndromes that predispose individuals to OSA due to associated anatomical features.
The rising incidence of obesity is a major contributing factor to the increased prevalence of OSA in recent decades.
Answer: True
Explanation: The rising incidence of obesity is a major contributing factor to the drastic increase in OSA prevalence observed in recent decades.
What temporary factor can cause transient episodes of OSA?
Answer: Upper respiratory infections.
Explanation: Upper respiratory infections, leading to nasal congestion and throat swelling, are a temporary factor that can cause transient episodes of OSA.
What is the significant link between obesity and the risk of obstructive sleep apnea?
Answer: Obesity is a major risk factor, with the risk for sleep apnea ranging between 55% and 90% in severely obese individuals.
Explanation: Obesity is a major risk factor for OSA, with a high prevalence of sleep apnea (55-90%) in severely obese individuals, often due to increased neck fat tissue.
What is a common anatomical cause of OSA in children that can sometimes be cured surgically?
Answer: Enlarged tonsils and adenoids.
Explanation: Enlarged tonsils and adenoids are a common anatomical cause of OSA in children, and their surgical removal (adenotonsillectomy) can often resolve the condition.
Which medical professionals primarily focus on structural features like enlarged tonsils or a floppy soft palate as causes of OSA?
Answer: Otorhinolaryngologists.
Explanation: Otorhinolaryngologists primarily focus on structural features such as enlarged tonsils, an enlarged posterior tongue, or a floppy soft palate as causes of OSA.
Which of the following is a recognized risk factor for OSA, beyond obesity?
Answer: Advanced age.
Explanation: Advanced age is a recognized risk factor for OSA, in addition to obesity.
How do genetic factors contribute to OSA susceptibility?
Answer: Through direct genetic contributions or indirect contributions via 'intermediate' phenotypes like craniofacial structure.
Explanation: Genetic factors contribute to OSA susceptibility through both direct genetic contributions and indirect contributions via 'intermediate' phenotypes such as craniofacial structure.
Which craniofacial syndrome is listed as predisposing individuals to OSA?
Answer: Down syndrome.
Explanation: Down syndrome is listed as a craniofacial syndrome that predisposes individuals to OSA due to associated anatomical features.
What is a major contributing factor to the drastic increase in OSA prevalence in recent decades?
Answer: The rising incidence of obesity.
Explanation: The rising incidence of obesity is identified as a major contributing factor to the drastic increase in OSA prevalence observed in recent decades.
Which gender difference is observed in OSA phenomenology?
Answer: Women with OSA have a higher mortality rate.
Explanation: While men are more frequently affected by OSA, women with OSA have been observed to have a higher mortality rate.
Most individuals with OSA are immediately aware of their breathing disturbances upon waking, making self-diagnosis common.
Answer: False
Explanation: Most individuals with OSA are unaware of their breathing disturbances during sleep, even after waking. Symptoms are often first noticed by a bed partner or family member, making self-diagnosis uncommon.
Loud snoring punctuated by periods of silence and gasps for air is a common symptom of obstructive sleep disorder syndrome in adults.
Answer: True
Explanation: Loud snoring, often interrupted by periods of silence followed by gasps for air, is a characteristic symptom of obstructive sleep disorder syndrome in adults.
Increased heart rate or blood pressure and erectile dysfunction are considered common symptoms of OSA in adults.
Answer: False
Explanation: Increased heart rate or blood pressure and erectile dysfunction are listed as less common symptoms of OSA in adults, not common ones.
Young children with severe OSA typically exhibit excessive daytime sleepiness, similar to adults.
Answer: False
Explanation: Unlike adults, young children with severe OSA usually present with hyperactivity and behavioral problems rather than overt excessive daytime sleepiness.
Young children with very severe OSA often exhibit 'failure to thrive' due to high calorie expenditure from breathing effort and discomfort during eating.
Answer: True
Explanation: Young children with very severe OSA are often thin and may experience 'failure to thrive' due to the high caloric expenditure associated with increased breathing effort and discomfort during feeding caused by obstructed passages.
A hypopnea is categorized as obstructive only if it involves a complete cessation of airflow, regardless of other symptoms.
Answer: False
Explanation: A hypopnea is categorized as obstructive if it is accompanied by snoring, increased oronasal flow flattening, or thoraco-abdominal paradoxical respiration, not necessarily complete cessation of airflow.
The Apnea-Hypopnea Index (AHI) measures the average number of apneas and hypopneas per hour of sleep, while the Respiratory Disturbance Index (RDI) includes these plus respiratory effort-related arousals (RERAs).
Answer: True
Explanation: The AHI quantifies the average number of apneas and hypopneas per hour of sleep, whereas the RDI is a broader measure that also incorporates respiratory effort-related arousals (RERAs).
For adults, an AHI of 10 events per hour indicates severe sleep apnea.
Answer: False
Explanation: For adults, an AHI of 10 events per hour indicates mild sleep apnea (5 to less than 15 events/hour), not severe sleep apnea (30 or more events/hour).
In children, an AHI of 5 or more events per hour is considered severe sleep apnea.
Answer: False
Explanation: In children, an AHI of 5 to less than 10 events per hour indicates moderate sleep apnea, while severe sleep apnea is characterized by 10 or more events per hour.
Nighttime in-laboratory Level 1 polysomnography (PSG) is the gold standard diagnostic test for OSA, involving monitoring various physiological parameters.
Answer: True
Explanation: Nighttime in-laboratory Level 1 polysomnography (PSG) is indeed considered the gold standard diagnostic test for OSA, involving comprehensive monitoring of physiological parameters.
Home sleep tests (HSTs) are generally more expensive and less accessible than in-lab polysomnography.
Answer: False
Explanation: Home sleep tests (HSTs) are more accessible and less expensive than in-lab polysomnography, offering an advantage in diagnosis.
One of the four main criteria for diagnosing OSA according to the International Classification of Sleep Disorders is the presence of associated medical issues like hypertension or type 2 diabetes.
Answer: True
Explanation: The presence of associated medical issues, including hypertension or type 2 diabetes, is one of the four main diagnostic criteria for OSA according to the International Classification of Sleep Disorders.
Why are individuals with OSA often unaware of their condition?
Answer: Most individuals are unaware of their breathing disturbances while sleeping, even after waking up.
Explanation: Individuals with OSA are often unaware of their condition because they do not perceive their breathing disturbances during sleep, even upon awakening.
Which of the following is a common symptom of obstructive sleep disorder syndrome in adults?
Answer: Loud snoring, often punctuated by periods of silence followed by gasps for air.
Explanation: Loud snoring, frequently interrupted by periods of silence and subsequent gasps for air, is a common and characteristic symptom of obstructive sleep disorder syndrome in adults.
Which of these is considered a *less common* symptom of OSA in adults?
Answer: Morning headaches.
Explanation: Morning headaches are listed as a less common symptom of OSA in adults, while unexplained daytime sleepiness, frequent awakenings, and loud snoring are common symptoms.
How does OSA typically manifest in young children compared to adults regarding behavior?
Answer: Young children with severe OSA usually behave as if they are 'over-tired' or 'hyperactive.'
Explanation: Unlike adults, young children with severe OSA commonly present with 'over-tired' or 'hyperactive' behaviors, along with irritability and attention deficits, rather than overt sleepiness.
Which of the following criteria must a hypopnea meet to be categorized as obstructive?
Answer: Increased oronasal flow flattening.
Explanation: For a hypopnea to be categorized as obstructive, it must meet criteria such as increased oronasal flow flattening, snoring, or thoraco-abdominal paradoxical respiration.
What does the Apnea-Hypopnea Index (AHI) measure?
Answer: The average number of apneas and hypopneas per hour of sleep.
Explanation: The Apnea-Hypopnea Index (AHI) measures the average number of apneas and hypopneas occurring per hour of sleep.
According to AHI thresholds for adults, what indicates moderate sleep apnea?
Answer: 15 to less than 30 events per hour.
Explanation: For adults, an AHI of 15 to less than 30 events per hour is classified as moderate sleep apnea.
What AHI threshold characterizes severe sleep apnea in children?
Answer: 10 or more events per hour.
Explanation: In children, severe sleep apnea is characterized by an AHI of 10 or more events per hour.
What is considered the 'gold standard' diagnostic test for OSA?
Answer: Nighttime in-laboratory Level 1 polysomnography (PSG).
Explanation: Nighttime in-laboratory Level 1 polysomnography (PSG) is recognized as the 'gold standard' diagnostic test for OSA.
What is a main advantage of using home sleep tests (HSTs) for OSA diagnosis?
Answer: They record sleep in the patient's usual environment and are more accessible.
Explanation: A primary advantage of home sleep tests (HSTs) is their ability to record sleep in the patient's usual environment, offering greater accessibility and potentially more representative data than in-lab studies.
Which of the following is one of the four main criteria for diagnosing OSA according to the International Classification of Sleep Disorders?
Answer: Observed snoring or breathing interruptions during sleep.
Explanation: Observed snoring or breathing interruptions during sleep is one of the four main criteria for diagnosing OSA according to the International Classification of Sleep Disorders.
Hypoxia related to OSA primarily causes changes in the neurons of the cerebellum, leading to motor coordination problems.
Answer: False
Explanation: Hypoxia associated with OSA primarily causes neuronal changes in the hippocampus and the right frontal cortex, leading to cognitive impairments, not motor coordination problems related to the cerebellum.
The three levels of consequences associated with OSA are primarily behavioral, psychological, and social.
Answer: False
Explanation: The three levels of consequences associated with OSA are categorized as physiologic, intermediate, and clinical, not primarily behavioral, psychological, and social.
Untreated OSA in children can lead to long-term adverse consequences affecting organs, body systems, behavior, and quality of life.
Answer: True
Explanation: Untreated OSA in children can indeed result in long-term adverse consequences across multiple domains, including organs, body systems, behavior, and overall quality of life.
Children with OSA commonly show improved academic performance and higher IQ scores due to increased alertness.
Answer: False
Explanation: Children with OSA commonly exhibit neurocognitive impairments, leading to lower academic performance and IQ scores, not improvements.
OSA in children is linked to a higher risk for cardiovascular diseases, including systemic hypertension and pulmonary hypertension.
Answer: True
Explanation: OSA in children is associated with an increased risk for cardiovascular diseases, such as systemic hypertension and pulmonary hypertension.
Nocturnal enuresis (bedwetting) in children with OSA is hypothesized to be caused by reduced urine production and enhanced bladder control.
Answer: False
Explanation: Nocturnal enuresis in children with OSA is hypothesized to be caused by excessive urine production, impaired bladder performance, or an inability to suppress nocturnal bladder contraction, not reduced urine production or enhanced bladder control.
Untreated OSA in children can lead to stunted growth because disrupted sleep compromises human growth hormone (HGH) secretion.
Answer: True
Explanation: Untreated OSA in children can result in stunted growth due to compromised human growth hormone (HGH) secretion, which is typically released during deep sleep.
Adults with OSA commonly experience cognitive improvements in attention and memory due to increased brain activity during sleep disturbances.
Answer: False
Explanation: Adults with OSA commonly experience cognitive impairments in attention and memory, not improvements, due to sleep fragmentation, sleep deprivation, and hypoxia.
Excessive daytime sleepiness (EDS) is reported by nearly all adult OSA patients and is the most significant behavioral impact.
Answer: False
Explanation: Excessive daytime sleepiness (EDS) is reported by approximately 30% of adult OSA patients, not nearly all, but it is considered the most significant behavioral impact.
Treating OSA in adults can reduce psychiatric symptoms and improve conditions like hypertension and metabolic syndrome components.
Answer: True
Explanation: Treating OSA in adults can indeed reduce psychiatric symptoms and improve associated conditions such as hypertension and components of the metabolic syndrome.
The relationship between Type 2 diabetes and OSA is unidirectional, with diabetes causing OSA but not vice versa.
Answer: False
Explanation: The relationship between Type 2 diabetes and OSA can be bidirectional, with OSA affecting glucose metabolism and diabetes potentially affecting the respiratory system.
Psychological disorders like depression and anxiety are linked to OSA in adults, and treating OSA can alleviate these symptoms.
Answer: True
Explanation: Psychological disorders such as depression and anxiety are linked to OSA in adults, and effective treatment of OSA can lead to an alleviation of these psychiatric symptoms.
Untreated OSA carries an increased risk of stroke, heart attack, and high blood pressure, but not diabetes or weight gain.
Answer: False
Explanation: Untreated OSA carries an increased risk of stroke, heart attack, and high blood pressure, and also contributes to diabetes and weight gain.
How does hypoxia related to OSA impact the adult brain?
Answer: It causes changes in the neurons of the hippocampus and the right frontal cortex.
Explanation: The hypoxia associated with OSA can cause neuronal changes in the hippocampus and the right frontal cortex, potentially leading to cognitive impairments.
Which of these is a 'physiologic' consequence associated with OSA?
Answer: Hypoxia.
Explanation: Hypoxia is categorized as a 'physiologic' consequence associated with OSA.
What is a long-term implication of untreated OSA in children?
Answer: Behavioral disturbances and depression.
Explanation: Long-term implications of untreated OSA in children include behavioral disturbances and depression, among other adverse effects.
Children with OSA commonly show neurocognitive impairments in which area?
Answer: Attention and concentration.
Explanation: Children with OSA commonly exhibit neurocognitive impairments in areas such as attention and concentration.
What cardiovascular issue is linked to OSA in children?
Answer: Pulmonary hypertension.
Explanation: Pulmonary hypertension is a cardiovascular issue linked to OSA in children.
What is a hypothesized cause of nocturnal enuresis (bedwetting) in children with OSA?
Answer: Excessive urine production.
Explanation: Excessive urine production is a hypothesized cause of nocturnal enuresis in children with OSA.
How can untreated OSA affect a child's physical growth?
Answer: It can lead to stunted growth by compromising human growth hormone (HGH) secretion.
Explanation: Untreated OSA can lead to stunted growth in children by compromising the secretion of human growth hormone (HGH) during disrupted sleep.
Which cognitive impairment is commonly observed in adults with OSA?
Answer: Deficits in attention.
Explanation: Deficits in attention are a commonly observed cognitive impairment in adults with OSA.
What is the most significant behavioral impact of OSA in adults, reported by approximately 30% of patients?
Answer: Excessive daytime sleepiness (EDS).
Explanation: Excessive daytime sleepiness (EDS), reported by approximately 30% of OSA patients, is considered the most significant behavioral impact of OSA in adults.
What serious physiological condition is linked to OSA in adults?
Answer: Increased risk for stroke.
Explanation: Untreated OSA in adults is linked to a serious physiological condition: an increased risk for stroke.
What is the relationship between Type 2 diabetes and OSA?
Answer: The relationship can be bidirectional, with OSA affecting glucose metabolism and diabetes affecting the respiratory system.
Explanation: The relationship between Type 2 diabetes and OSA is bidirectional, meaning OSA can affect glucose metabolism, and diabetes-related nerve dysfunction can impact the respiratory system.
Which psychological consequence is linked to OSA in adults?
Answer: Depression.
Explanation: Depression is a psychological consequence linked to OSA in adults, often due to impaired sleep quality and recurrent hypoxia.
What is a serious long-term health consequence of untreated OSA?
Answer: Increased risk of stroke.
Explanation: A serious long-term health consequence of untreated OSA is an increased risk of stroke.
General management for OSA includes avoiding alcohol and smoking, and weight loss for overweight individuals.
Answer: True
Explanation: General management recommendations for OSA include avoiding alcohol and smoking, and implementing weight loss strategies for individuals who are overweight or obese.
Continuous Positive Airway Pressure (CPAP) works by delivering negative pressure to pull the airway open.
Answer: False
Explanation: Continuous Positive Airway Pressure (CPAP) works by delivering *positive* pressure to hold the airway open, not negative pressure.
Nasal EPAP is a variant of positive airway pressure therapy that uses a bandage-like device to create positive airway pressure from a person's own breathing.
Answer: True
Explanation: Nasal EPAP is a variant of positive airway pressure therapy that utilizes a bandage-like device to generate positive airway pressure from the individual's own breathing.
CPAP compliance is high, with most users continuing treatment for several years without issues.
Answer: False
Explanation: CPAP compliance is challenging, with a significant percentage of users discontinuing treatment within the first year, indicating that compliance is not consistently high.
Sleeping on one's back (supine position) is recommended over side sleeping as a non-device physical intervention for OSA.
Answer: False
Explanation: Sleeping on one's side is recommended over sleeping on the back (supine position) as a non-device physical intervention for OSA.
Playing a wind instrument like a didgeridoo may help reduce snoring and apnea incidents by strengthening throat muscles.
Answer: True
Explanation: Some studies suggest that playing wind instruments, such as a didgeridoo, may help reduce snoring and apnea incidents by strengthening the muscles around the mouth and throat.
Fluoxetine and paroxetine are FDA-approved medications for directly treating the underlying cause of obstructive sleep apnea.
Answer: False
Explanation: There is currently insufficient evidence to support the widespread use of medications like fluoxetine and paroxetine for directly treating the underlying cause of obstructive sleep apnea.
Modafinil and armodafinil are approved medications for managing the symptom of excessive daytime sleepiness associated with OSA.
Answer: True
Explanation: Modafinil and armodafinil are among the approved medications for managing the symptom of excessive daytime sleepiness associated with OSA.
Tirzepatide (Zepbound) was approved in December 2024 as the first medication specifically for the treatment of obesity-related OSA.
Answer: True
Explanation: Tirzepatide (Zepbound) received FDA approval in December 2024, marking it as the first medication specifically for the treatment of obesity-related OSA.
Mandibular advancement splints (MAS) are primarily recommended for individuals with severe OSA and poor dentition.
Answer: False
Explanation: Mandibular advancement splints (MAS) are most suitable for individuals with mild to moderate OSA, an AHI less than 25, a BMI less than 30, and good dentition, not primarily for severe OSA with poor dentition.
Rapid Palatal Expansion (RPE) is an orthodontic treatment that expands the nasal airway volume, with MARPE being a non-surgical option for adults.
Answer: True
Explanation: Rapid Palatal Expansion (RPE) is an orthodontic treatment designed to expand the nasal airway volume, and MARPE is a non-surgical variant for adults.
Surgical intervention is the first-line treatment for adults with obstructive sleep apnea.
Answer: False
Explanation: Surgical intervention is not considered a first-line treatment for adults with OSA; it is typically reserved for patients unable or unwilling to comply with first-line treatments like CPAP.
Which of the following is a general management recommendation for obstructive sleep apnea?
Answer: Avoiding smoking.
Explanation: Avoiding smoking is a general management recommendation for obstructive sleep apnea.
How does Continuous Positive Airway Pressure (CPAP) primarily treat OSA?
Answer: By delivering a controlled stream of air to hold open the relaxed upper airway muscles.
Explanation: CPAP primarily treats OSA by delivering a controlled stream of air that maintains positive pressure, thereby holding open the relaxed upper airway muscles.
Which variant of positive airway pressure therapy monitors breathing and provides different pressures for inhalation and exhalation?
Answer: Variable Positive Airway Pressure (VPAP).
Explanation: Variable Positive Airway Pressure (VPAP), also known as bilevel (BiPAP or BPAP), monitors breathing and provides different pressures for inhalation and exhalation.
What is a common challenge with CPAP compliance?
Answer: A significant percentage of users discontinue within the first year.
Explanation: A common challenge with CPAP compliance is that a significant percentage of users discontinue treatment within the first year, often due to required behavioral changes.
Which non-device physical intervention is recommended for managing OSA?
Answer: Sleeping with the upper body elevated at a 30-degree angle or higher.
Explanation: Sleeping with the upper body elevated at a 30-degree angle or higher is a recommended non-device physical intervention for managing OSA.
What type of musical activity has been suggested as a potential aid in reducing snoring and apnea incidents?
Answer: Playing a wind instrument like a didgeridoo.
Explanation: Playing a wind instrument, such as a didgeridoo, has been suggested as a potential aid in reducing snoring and apnea incidents by strengthening throat muscles.
Which medications are approved for managing the *symptom* of excessive daytime sleepiness associated with OSA?
Answer: Solriamfetol and modafinil.
Explanation: Solriamfetol and modafinil are approved medications specifically for managing the symptom of excessive daytime sleepiness associated with OSA.
What was the significance of the FDA approval of tirzepatide (Zepbound) in December 2024?
Answer: It was the first medication specifically for the treatment of obesity-related OSA.
Explanation: The FDA approval of tirzepatide (Zepbound) in December 2024 was significant as it marked the first medication specifically for the treatment of obesity-related OSA.
For which patients are Mandibular Advancement Splints (MAS) most suitable?
Answer: Individuals with mild to moderate obstructive sleep apnea, an AHI less than 25, a BMI less than 30, and good dentition.
Explanation: Mandibular Advancement Splints (MAS) are most suitable for individuals with mild to moderate OSA, specific AHI and BMI criteria, and good dentition.
What is the purpose of Rapid Palatal Expansion (RPE) in treating OSA?
Answer: To expand the volume of the nasal airway.
Explanation: The purpose of Rapid Palatal Expansion (RPE) in treating OSA is to expand the volume of the nasal airway, thereby improving airflow.
When is surgical intervention typically considered for adults with obstructive sleep apnea?
Answer: For patients who are unable or unwilling to comply with first-line treatments like CPAP and oral appliances.
Explanation: Surgical intervention for adults with OSA is typically considered for patients who cannot or will not comply with first-line treatments such as CPAP and oral appliances.