Who is Chi-Huey Wong, and what is his primary professional identity?

Chi-Huey Wong is a Taiwanese-American biochemist. He is currently recognized as the Scripps Family Chair Professor at the Scripps Research Institute.

What significant national and international recognitions has Chi-Huey Wong received?

Chi-Huey Wong is a member of the United States National Academy of Sciences. He was also awarded the 2014 Wolf Prize in Chemistry and the 2015 RSC Robert Robinson Award, highlighting his significant contributions to the field.

How extensive is Chi-Huey Wong's published work in terms of patents and academic papers?

Chi-Huey Wong is a prolific researcher, holding more than 100 patents and having published over 700 scholarly academic research papers throughout his career.

When and where was Chi-Huey Wong born?

Chi-Huey Wong was born on August 3, 1948, in Yizhu, Tainan County, Taiwan, which is now part of Chiayi County.

What academic degrees did Chi-Huey Wong obtain from National Taiwan University?

Chi-Huey Wong earned both his Bachelor of Science (B.S.) in 1970 and Master of Science (M.S.) in 1977, both in biochemical sciences, from National Taiwan University.

From which institution did Chi-Huey Wong receive his Ph.D., and what was his area of study?

Chi-Huey Wong completed his graduate studies in the United States, earning his Ph.D. in organic chemistry in 1982 from the Massachusetts Institute of Technology (MIT).

Who was Chi-Huey Wong's Ph.D. advisor at MIT, and what was the focus of his doctoral research?

At MIT, Chi-Huey Wong conducted his Ph.D. research under the direction of Professor George M. Whitesides, focusing on the innovative use of enzymes as catalysts in organic synthesis.

Where did Chi-Huey Wong conduct his postdoctoral research?

Following his Ph.D., Chi-Huey Wong continued his postdoctoral research work with George M. Whitesides at Harvard University from 1982 to 1983.

Where did Chi-Huey Wong begin his independent academic career?

Chi-Huey Wong began his independent academic career at Texas A&M University, joining its chemistry department.

What was Chi-Huey Wong's progression through the academic ranks at Texas A&M University?

During his tenure at Texas A&M University, Chi-Huey Wong advanced through the academic ranks, serving as an assistant professor, associate professor, and ultimately, a full professor of chemistry.

What distinguished professorship did Chi-Huey Wong hold at the Scripps Research Institute?

Chi-Huey Wong was appointed as the Ernest W. Hahn Chair and professor of chemistry at the Scripps Research Institute.

What was Chi-Huey Wong's highest administrative position in Taiwan, and who appointed him?

Chi-Huey Wong was appointed as the 8th President of Academia Sinica by the President of the Republic of China (Taiwan).

What is Chi-Huey Wong's current position after his presidency at Academia Sinica?

Currently, Chi-Huey Wong is serving at the Scripps Research Institute as the Scripps Family Chair Professor of Chemistry.

What is glycoscience, the field to which Chi-Huey Wong made original contributions?

Chi-Huey Wong is best known for his original contributions to glycoscience, which is the study of the structure, biosynthesis, and biology of glycans (carbohydrates) and their roles in biological systems.

What specific synthetic methods did Chi-Huey Wong develop for oligosaccharides and glycoproteins?

Chi-Huey Wong developed chemo-enzymatic methods for the practical synthesis of oligosaccharides and glycoproteins. These methods combine chemical reactions with enzymatic catalysis to efficiently build complex carbohydrate structures.

What innovative synthesis method did Wong introduce for the rapid preparation of oligosaccharides?

Wong introduced the hierarchical and programmable one-pot synthesis method, which allows for the rapid preparation of a large number of oligosaccharides in a single reaction vessel.

How did Wong's work on glycan microarrays advance the study of biological interactions?

Wong's work included the development of glycan microarrays, which are high-throughput tools used for the analysis of protein-carbohydrate interactions, enabling researchers to quickly screen many interactions simultaneously.

What clinical applications have emerged from Chi-Huey Wong's research in carbohydrate-based medicines?

Wong's research has led to the clinical development of carbohydrate-based medicines, including vaccines and homogeneous antibodies, which are used for the treatment of cancers and infectious diseases.

What controversy did Chi-Huey Wong face in 2016 regarding a biotech company?

In 2016, media reports speculated that Chi-Huey Wong was involved in an insider trading scandal related to OBI Pharma, Inc., a biotech company headquartered in Taiwan, because his adult daughter held shares in the company.

How did Chi-Huey Wong react to the insider trading allegations, and what was the initial response from the President of Taiwan?

Wong was disappointed by the false report and attempted to resign his position as president of the Academia Sinica twice. However, both of his resignation requests were initially rejected by the then-President of Taiwan, Ma Ying-jeou.

When was Chi-Huey Wong's resignation as President of Academia Sinica finally approved?

After further consideration, President Ma Ying-jeou chose to approve Chi-Huey Wong's resignation on May 10, 2016.

What was the legal outcome of the insider trading charges against Chi-Huey Wong?

In February 2018, the Shilin District Prosecutors Office announced that the charges of insider trading against Chi-Huey Wong had been dropped.

What was the final resolution regarding the investigation into Chi-Huey Wong's asset disclosure?

In April 2022, the Control Yuan publicly announced that Chi-Huey Wong did not violate any rule concerning the disclosure of his assets during the tech transfer of his invention.

Which awards did Chi-Huey Wong receive in 1985 and 1986?

In 1985, Chi-Huey Wong received the Searle Scholar Award, and in 1986, he was honored with the Presidential Young Investigator Award in Chemistry.

What international carbohydrate award did Chi-Huey Wong receive in 1994?

Chi-Huey Wong was awarded the IUPAC International Carbohydrate Award in 1994, recognizing his contributions to carbohydrate chemistry.

Name two awards Chi-Huey Wong received from the American Chemical Society in 1998 and 1999.

Chi-Huey Wong received the Harrison Howe Award from the American Chemical Society in 1998 and the Claude S. Hudson Award from the same society in 1999.

When did Chi-Huey Wong receive the United States Presidential Green Chemistry Award?

Chi-Huey Wong was honored with the United States Presidential Green Chemistry Award in 2000, which recognizes innovations that reduce the environmental impact of chemical products and processes.

What award did Chi-Huey Wong receive from the American Chemical Society in 2005?

In 2005, Chi-Huey Wong received the American Chemical Society Award for Creative Work in Synthetic Organic Chemistry.

Which medal for excellence in chemical research was awarded to Chi-Huey Wong in 2008?

Chi-Huey Wong was awarded the F.A. Cotton Medal for Excellence in Chemical Research in 2008.

In what year did Chi-Huey Wong receive the Arthur C. Cope Award from the American Chemical Society?

Chi-Huey Wong received the prestigious Arthur C. Cope Award from the American Chemical Society in 2012.

When was Chi-Huey Wong recognized with the Robert Robinson Award by the Royal Society of Chemistry?

Chi-Huey Wong received the Robert Robinson Award from the Royal Society of Chemistry in 2015.

In which years was Chi-Huey Wong featured on the 'Asian Scientist 100' list?

Chi-Huey Wong was recognized on the 'Asian Scientist 100' list by Asian Scientist magazine in both 2016 and 2022.

In what year was Chi-Huey Wong honored with the Welch Award in Chemistry?

Chi-Huey Wong received the Welch Award in Chemistry in 2021, an award that recognizes outstanding achievements in chemical research.

Which award did Chi-Huey Wong receive from the American Institute of Chemists in 2022?

In 2022, Chi-Huey Wong was honored with the Chemical Pioneer Award of the American Institute of Chemists.

What two awards did Chi-Huey Wong receive in 2023?

In 2023, Chi-Huey Wong received the Israel Chemical Society International Barry Cohen Award and the Federation of Asian Chemical Societies (FACS) Foundation Lectureship Award.

Name two institutions that awarded Chi-Huey Wong honorary doctorates in 2007.

In 2007, Chi-Huey Wong received honorary doctorates from Technion – Israel Institute of Technology in Israel and National Yang-Ming University in Taiwan.

Which universities in Taiwan granted Chi-Huey Wong honorary doctorates between 2008 and 2011?

Between 2008 and 2011, Chi-Huey Wong received honorary doctorates from National Sun Yat-sen University (2008), National Chung Hsing University (2010), National Chiao Tung University (2011), and National Tsing-Hua University (2011), all in Taiwan.

When was Chi-Huey Wong elected as a member of Academia Sinica and the American Academy of Arts and Science?

Chi-Huey Wong was elected as a member of Academia Sinica in 1994 and the American Academy of Arts and Science in 1996.

In what year did Chi-Huey Wong become a member of the United States National Academy of Sciences?

Chi-Huey Wong became a member of the United States National Academy of Sciences in 2002.

What international scientific organizations did Chi-Huey Wong join in 2007 and 2010?

In 2007, Chi-Huey Wong joined the World Academy of Sciences, and in 2010, he became an Associate Member of the European Molecular Biology Organization.

What was the title of Chi-Huey Wong's 1994 publication by Pergamon Press?

Chi-Huey Wong's 1994 publication by Pergamon Press was titled 'Enzymes in Synthetic Organic Chemistry'.

Which book related to carbohydrate-based drug discovery did Chi-Huey Wong publish in 2003?

In 2003, Chi-Huey Wong published the book 'Carbohydrate Based Drug Discovery' through Wiley Online Library.

Can you name one of Chi-Huey Wong's representative patents related to anti-cancer vaccines?

One of Chi-Huey Wong's representative patents is 'Globo-H and related anti-cancer vaccines with novel glycolipid adjuvants' (US9,603,913B2).

What was the subject of Wong's patent US8,680,020?

Wong's patent US8,680,020 describes 'Glycan arrays on PTFE-like aluminum coated glass slides and related methods'.

What type of methods did Wong patent for modifying human antibodies?

Wong patented 'Methods for modifying human antibodies by glycan engineering' (US10,087,236).

What was the focus of Wong's patent US9890111B2?

Wong's patent US9890111B2 focused on the 'Crystal structure of bifunctional transglycosylase PBP1b from E. Coli and inhibitors thereof'.

Which patent by Wong describes methods for treating sepsis and related inflammatory responses?

The patent US8486914B2 by Wong describes 'Hirsutella Sinensis mycelia compositions and methods for treating sepsis and related inflammatory responses'.

What is the native form of Chi-Huey Wong's personal name, as mentioned in the article?

The native form of Chi-Huey Wong's personal name is Wong Chi-Huey, which is a common naming convention in some East Asian cultures where the family name precedes the given name.

What was the duration of Chi-Huey Wong's term as the 8th President of the Academia Sinica?

Chi-Huey Wong served as the 8th President of the Academia Sinica from October 19, 2006, to May 10, 2016.

Chi-huey Wong Wiki: Chi-Huey Wong: A Luminary in Glycoscience

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Introduction

A Distinguished Biochemist

Chi-Huey Wong, a distinguished Taiwanese-American biochemist, currently holds the Scripps Family Chair Professorship at the Scripps Research Institute. Born on August 3, 1948, in Yizhu, Tainan County (now Chiayi County), Taiwan, Professor Wong has carved an indelible mark in the scientific community through his groundbreaking work in glycoscience.

Acclaimed Recognition

His exceptional contributions have garnered significant international acclaim. He is an esteemed member of the United States National Academy of Sciences and a recipient of numerous prestigious awards, including the 2014 Wolf Prize in Chemistry and the 2015 RSC Robert Robinson Award. These accolades underscore his profound impact on the field of chemistry and biochemistry.

Prolific Innovator

Professor Wong is a prolific innovator and scholar, holding over 100 patents for his inventions. His extensive research is documented in more than 700 scholarly academic research papers, reflecting a career dedicated to advancing scientific understanding and developing practical applications in carbohydrate-based medicine.

Academic Journey

Early Foundations in Taiwan

Professor Wong commenced his higher education at National Taiwan University, where he earned both his Bachelor of Science (B.S.) in 1970 and his Master of Science (M.S.) in biochemical sciences in 1977. These formative years established a strong foundation for his future endeavors in chemical research.

Doctoral Studies at MIT

He subsequently pursued graduate studies in the United States, culminating in a Ph.D. in organic chemistry from the Massachusetts Institute of Technology (MIT) in 1982. Under the mentorship of Professor George M. Whitesides, his doctoral research focused on the innovative application of enzymes as catalysts in organic synthesis, a field that would become central to his career.

Professional Trajectory

Postdoctoral and Early Academia

Following his Ph.D., Professor Wong continued his postdoctoral research with George M. Whitesides at Harvard University from 1982 to 1983. He then embarked on his independent academic career at Texas A&M University, where he progressed through the ranks from assistant professor to full professor in the chemistry department, establishing his research group and reputation.

Global Leadership Roles

His career path led him to the Scripps Research Institute as the Ernest W. Hahn Chair and Professor of Chemistry. Concurrently, he held significant leadership positions internationally, serving as the head of the Frontier Research Program on Glycotechnology at Riken in Japan and as the director of the Genomics Research Center at Academia Sinica in Taiwan. His leadership extended further when he was appointed by the President of the Republic of China (Taiwan) as the President of Academia Sinica.

Current Affiliation

Presently, Professor Wong continues his impactful work at the Scripps Research Institute, where he holds the prestigious Scripps Family Chair Professorship of Chemistry, maintaining his active role in cutting-edge scientific discovery and mentorship.

Pioneering Research

Innovations in Glycoscience

Professor Wong is widely recognized for his seminal contributions to glycoscience. His research has focused on developing chemo-enzymatic methods for the practical synthesis of complex carbohydrates, specifically oligosaccharides and glycoproteins. These methods have revolutionized the accessibility and study of these vital biological molecules.

Hierarchical Synthesis & Microarrays

A notable achievement is his development of a hierarchical and programmable one-pot synthesis method, enabling the rapid preparation of a vast array of oligosaccharides. Furthermore, his work on glycan microarrays has provided high-throughput analytical tools for studying protein-carbohydrate interactions, crucial for understanding biological processes.

Therapeutic Applications

The synthetic methods and glycosylation probes pioneered by Wong have not only advanced the fundamental understanding of glycosylation in biology but have also paved the way for the clinical development of carbohydrate-based medicines. This includes innovative vaccines and homogeneous antibodies designed for the treatment of cancers and infectious diseases, demonstrating a direct translational impact on human health.

Public Scrutiny & Resolution

Allegations of Insider Trading

In 2016, Professor Wong faced media speculation regarding his potential involvement in an insider trading scandal linked to OBI Pharma, Inc., a biotech company based in Taiwan. The allegations arose because his adult daughter held shares in the company.

Resignation and Investigation

While in the United States, Professor Wong expressed deep disappointment over the false reports and twice offered his resignation as President of Academia Sinica. Initially rejected, his resignation was eventually approved by then-President Ma Ying-jeou on May 10, 2016. An investigation into the matter ensued.

Exoneration

In February 2018, the Shilin District Prosecutors Office officially announced that all charges of insider trading against Professor Wong had been dropped. Subsequently, in April 2022, the Control Yuan publicly confirmed that Professor Wong had not violated any regulations concerning the disclosure of assets during the technology transfer of his inventions, fully clearing his name.

Awards & Honors

Major Accolades

Professor Chi-Huey Wong has been honored with a remarkable array of awards throughout his distinguished career, recognizing his profound impact on chemistry and biochemistry.

1985 – Searle Scholar Award
1986 – Presidential Young Investigator Award in Chemistry
1994 – IUPAC International Carbohydrate Award
1998 – Harrison Howe Award, American Chemical Society
1999 – International Enzyme Engineering Award
1999 – Claude S. Hudson Award, American Chemical Society
2000 – United States Presidential Green Chemistry Award
2005 – American Chemical Society Award for Creative Work in Synthetic Organic Chemistry
2008 – F.A. Cotton Medal for Excellence in Chemical Research
2012 – Arthur C. Cope Award by the American Chemical Society
2014 – Wolf Prize in Chemistry
2015 – Robert Robinson Award, Royal Society of Chemistry
2016 and 2022 – Asian Scientist 100, Asian Scientist
2021 – Welch Award in Chemistry
2022 – Chemical Pioneer Award of the American Institute of Chemists
2023 – Israel Chemical Society International Barry Cohen Award
2023 – Federation of Asian Chemical Societies (FACS) Foundation Lectureship Award

Honorary Doctorates

In recognition of his scholarly achievements and leadership, several prestigious institutions have bestowed upon Professor Wong honorary doctorates.

2007 – Technion – Israel Institute of Technology, Israel
2007 – National Yang-Ming University, Taiwan (now NYCU)
2008 – National Sun Yat-sen University, Taiwan
2009 – City University of Hong Kong, Hong Kong SAR
2010 – National Chung Hsing University, Taiwan
2011 – National Chiao Tung University, Taiwan (now NYCU)
2011 – National Tsing-Hua University, Taiwan

Distinguished Memberships

Global Scientific Societies

Professor Chi-Huey Wong's influence extends through his memberships in numerous elite scientific academies and organizations worldwide, reflecting his standing as a leading figure in global science.

1994 – Academia Sinica
1996 – American Academy of Arts and Science
2002 – United States National Academy of Sciences
2007 – The World Academy of Sciences
2010 – Associate Member of the European Molecular Biology Organization
2014 – United States National Academy of Inventors

Patents & Publications

Extensive Bibliography

Beyond his numerous patents, Professor Wong has authored or co-authored over 700 scholarly academic research papers, contributing significantly to the scientific literature. His published works include foundational texts in the field of synthetic organic chemistry and carbohydrate-based drug discovery.

Enzymes in Synthetic Organic Chemistry. Pergamon Press. 1994. ISBN 978-0-08-050582-4
Carbohydrate Based Drug Discovery. Wiley Online Library. 2003. ISBN 978-3-527-60243-8
Current Status and New Challenges in Glycoscience. Springer. ISBN 978-4-431-54841-6

Representative Patents

Professor Wong's innovative spirit is further evidenced by his extensive patent portfolio, which includes over 100 patents. These patents cover a wide range of inventions, from novel synthetic methods to therapeutic compositions.

Globo-H and related anti-cancer vaccines with novel glycolipid adjuvants (US9,603,913B2)
Glycan arrays on PTFE-like aluminum coated glass slides and related methods (US8,680,020)
Methods and compositions for immunization against virus (US8.741,311)
Large scale enzymatic synthesis of oligosaccharides (US9,340,812)
Methods for modifying human antibodies by glycan engineering (US10, 087,236)
Compositions and methods relating to universal glycoforms for enhanced antibody efficacy (US10,023892)
Crystal structure of bifunctional transglycosylase PBP1b from E. Coli and inhibitors thereof (US9890111B2)
Quantitative analysis of carbohydrate-protein interactions using glycan microarrays: determination of surface and solution dissociation constants (US-8906832-B2)
Antibiotic compositions and related screening methods (US8916540B2)
Hirsutella Sinensis mycelia compositions and methods for treating sepsis and related inflammatory responses (US8486914B2)
Tailored glycoproteomic methods for the sequencing, mapping and identification of cellular glycoproteins (US7943330B2)

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References

Wolf Prize in Chemistry 2014

Welch Award in Chemistry 2021

A full list of references for this article are available at the Chi-Huey Wong Wikipedia page

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Important Notice

This page was generated by an Artificial Intelligence and is intended for informational and educational purposes only. The content is based on a snapshot of publicly available data from Wikipedia and may not be entirely accurate, complete, or up-to-date.

This is not professional scientific or academic advice. The information provided on this website is not a substitute for consulting original research papers, official academic publications, or seeking advice from qualified biochemists, chemists, or other scientific professionals. Always refer to primary scientific literature and consult with experts for specific research or academic inquiries. Never disregard professional scientific advice because of something you have read on this website.

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Chi-Huey Wong: A Luminary in Glycoscience

💡 Dive in with Flashcard Learning! 💡

Introduction 🌟

👨‍🔬 A Distinguished Biochemist

🏆 Acclaimed Recognition

📚 Prolific Innovator

Academic Journey 🎓

🇹🇼 Early Foundations in Taiwan

🇺🇸 Doctoral Studies at MIT

Professional Trajectory 💼

🔬 Postdoctoral and Early Academia

🌐 Global Leadership Roles

🌟 Current Affiliation

Pioneering Research 🧪

🍬 Innovations in Glycoscience

🔗 Hierarchical Synthesis & Microarrays

💉 Therapeutic Applications

Public Scrutiny & Resolution ⚖️

📰 Allegations of Insider Trading

📝 Resignation and Investigation

✅ Exoneration

Awards & Honors 🏅

🏆 Major Accolades

📜 Honorary Doctorates

Distinguished Memberships 🤝

🌍 Global Scientific Societies

Patents & Publications 💡

📜 Extensive Bibliography

🛡️ Representative Patents

Teacher's Corner 🧑‍🏫

Edit and Print this course in the Wiki2Web Teacher Studio

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References

📜 References

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Disclaimer ⚠️

📜 Important Notice

Dive in with Flashcard Learning!

Introduction

A Distinguished Biochemist

Acclaimed Recognition

Prolific Innovator

Academic Journey

Early Foundations in Taiwan

Doctoral Studies at MIT

Professional Trajectory

Postdoctoral and Early Academia

Global Leadership Roles

Current Affiliation

Pioneering Research

Innovations in Glycoscience

Hierarchical Synthesis & Microarrays

Therapeutic Applications

Public Scrutiny & Resolution

Allegations of Insider Trading

Resignation and Investigation

Exoneration

Awards & Honors

Major Accolades

Honorary Doctorates

Distinguished Memberships

Global Scientific Societies

Patents & Publications

Extensive Bibliography

Representative Patents

Teacher's Corner

True or False?

Test Your Knowledge!

Gamer's Corner

Discover other topics to study!

References

Feedback & Support

Disclaimer

Important Notice