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NPC1L1 Protein: Function, Genetics, and Identifiers

At a Glance

Title: NPC1L1 Protein: Function, Genetics, and Identifiers

Total Categories: 5

Category Stats

  • NPC1L1: Molecular and Cellular Biology: 11 flashcards, 13 questions
  • NPC1L1: Cholesterol Metabolism and Absorption: 5 flashcards, 8 questions
  • NPC1L1: Pharmacology and Therapeutic Applications: 7 flashcards, 10 questions
  • NPC1L1: Genetics and Disease Association: 7 flashcards, 8 questions
  • NPC1L1: Bioinformatics and Database Identifiers: 13 flashcards, 18 questions

Total Stats

  • Total Flashcards: 43
  • True/False Questions: 30
  • Multiple Choice Questions: 27
  • Total Questions: 57

Instructions

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Step 1: Laying the Foundation (The Authoring Tools)

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⚙️ Kit Manager: Your Kit's Identity

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Step 2: The Magic (The Generator Suite)

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Study Guide: NPC1L1 Protein: Function, Genetics, and Identifiers

Study Guide: NPC1L1 Protein: Function, Genetics, and Identifiers

NPC1L1: Molecular and Cellular Biology

The protein NPC1L1 is exclusively expressed within the epithelial cells of the human gastrointestinal tract.

Answer: False

The protein NPC1L1 is expressed not only in the epithelial cells of the gastrointestinal tract but also in hepatocytes.

Related Concepts:

  • What are the primary anatomical locations of NPC1L1 protein expression in the human body?: The NPC1L1 protein is predominantly expressed in the epithelial cells lining the gastrointestinal tract and within hepatocytes, the principal functional cells of the liver.
  • What is the significance of the NPC1L1 protein's presence on the brush border membrane?: The Gene Ontology lists NPC1L1 as being associated with the brush border membrane, which is a characteristic feature of cells lining the small intestine, suggesting a role in absorption processes occurring there.
  • Based on Bgee data, what are the primary mouse tissues demonstrating significant NPC1L1 RNA expression?: Bgee data indicates that NPC1L1 RNA is highly expressed in mouse tissues such as the epithelium of the small intestine, jejunum, ileum, duodenum, migratory enteric neural crest cells, embryos, Paneth cells, morulae, blastocysts, and the yolk sac.

According to Bgee data, NPC1L1 RNA expression is notably high in the human jejunal mucosa.

Answer: True

Bgee expression data confirms high levels of NPC1L1 RNA expression in the human jejunal mucosa, among other tissues.

Related Concepts:

  • Based on Bgee data, what are the primary mouse tissues demonstrating significant NPC1L1 RNA expression?: Bgee data indicates that NPC1L1 RNA is highly expressed in mouse tissues such as the epithelium of the small intestine, jejunum, ileum, duodenum, migratory enteric neural crest cells, embryos, Paneth cells, morulae, blastocysts, and the yolk sac.
  • According to expression data from Bgee, in which human tissues does NPC1L1 exhibit the highest levels of RNA expression?: According to Bgee data, NPC1L1 RNA shows high expression in human tissues including the jejunal mucosa, duodenum, right lobe of the liver, testicles, islet of Langerhans, gallbladder, muscle layer of the sigmoid colon, right coronary artery, descending thoracic aorta, and popliteal artery.
  • What is the significance of the NPC1L1 protein's presence on the brush border membrane?: The Gene Ontology lists NPC1L1 as being associated with the brush border membrane, which is a characteristic feature of cells lining the small intestine, suggesting a role in absorption processes occurring there.

Gene Ontology assigns NPC1L1 the molecular function of DNA binding.

Answer: False

Gene Ontology does not assign DNA binding as a molecular function for NPC1L1; it is associated with functions such as myosin V binding and protein binding.

Related Concepts:

  • What specific molecular functions has the Gene Ontology assigned to the NPC1L1 protein?: The Gene Ontology has assigned the molecular functions of myosin V binding and protein binding to the NPC1L1 protein.
  • Beyond standard gene and protein databases, what other external resources offer information or related media for NPC1L1?: External resources offering information on NPC1L1 include the U.S. National Library of Medicine's Medical Subject Headings (MeSH), the PDBe-KB database, Wikidata, and Wikimedia Commons, which hosts related media.
  • In terms of cellular localization, what components does the Gene Ontology identify as being associated with NPC1L1?: The Gene Ontology identifies NPC1L1 as being associated with the membrane, plasma membrane, brush border membrane, apical plasma membrane, cytoplasmic vesicle membrane, cytoplasmic vesicle, integral component of membrane, and spanning component of plasma membrane.

The Gene Ontology lists NPC1L1 as being associated with the brush border membrane.

Answer: True

Gene Ontology annotations confirm NPC1L1's association with the brush border membrane, a structure characteristic of absorptive epithelial cells.

Related Concepts:

  • In terms of cellular localization, what components does the Gene Ontology identify as being associated with NPC1L1?: The Gene Ontology identifies NPC1L1 as being associated with the membrane, plasma membrane, brush border membrane, apical plasma membrane, cytoplasmic vesicle membrane, cytoplasmic vesicle, integral component of membrane, and spanning component of plasma membrane.
  • What is the significance of the NPC1L1 protein's presence on the brush border membrane?: The Gene Ontology lists NPC1L1 as being associated with the brush border membrane, which is a characteristic feature of cells lining the small intestine, suggesting a role in absorption processes occurring there.
  • What is the significance of NPC1L1 being located on the plasma membrane?: NPC1L1's presence on the plasma membrane, the outer boundary of the cell, is crucial for its function in interacting with substances from the extracellular environment, such as cholesterol or viruses.

NPC1L1's association with myosin V binding suggests it is involved in DNA replication.

Answer: False

The association with myosin V binding, a motor protein, suggests NPC1L1's involvement in intracellular transport mechanisms rather than DNA replication.

Related Concepts:

  • What does the reference to 'myosin V binding' in the Gene Ontology imply about NPC1L1's cellular activity?: The association with myosin V binding suggests that NPC1L1 may be involved in intracellular transport processes, as myosin V is a motor protein known to move cargo along actin filaments within cells.
  • What specific molecular functions has the Gene Ontology assigned to the NPC1L1 protein?: The Gene Ontology has assigned the molecular functions of myosin V binding and protein binding to the NPC1L1 protein.

NPC1L1 being an integral membrane component means it is only loosely attached to the cell surface.

Answer: False

An integral membrane component is embedded within the lipid bilayer, indicating a strong, non-covalent association, rather than being loosely attached.

Related Concepts:

  • What is the functional relevance of NPC1L1 being an 'integral component of membrane'?: Being an integral component of the membrane means that NPC1L1 is embedded within the cell's lipid bilayer, which is essential for its function as a receptor or transporter that interacts with molecules across the membrane boundary.
  • What is the significance of NPC1L1 being located on the plasma membrane?: NPC1L1's presence on the plasma membrane, the outer boundary of the cell, is crucial for its function in interacting with substances from the extracellular environment, such as cholesterol or viruses.
  • In terms of cellular localization, what components does the Gene Ontology identify as being associated with NPC1L1?: The Gene Ontology identifies NPC1L1 as being associated with the membrane, plasma membrane, brush border membrane, apical plasma membrane, cytoplasmic vesicle membrane, cytoplasmic vesicle, integral component of membrane, and spanning component of plasma membrane.

The NPC1L1 protein is classified as a mammalian protein found in Homo sapiens.

Answer: True

NPC1L1 is indeed classified as a mammalian protein, specifically found in Homo sapiens.

Related Concepts:

  • What is the general classification of NPC1L1 mentioned in the short description of the article?: The short description classifies NPC1L1 as a mammalian protein found in Homo sapiens.
  • What are the Entrez gene identification numbers for NPC1L1 in humans and mice?: The Entrez gene ID for human NPC1L1 is 29881, and for mouse NPC1L1, it is 237636.
  • What are the RefSeq protein accession numbers corresponding to the human NPC1L1 gene?: The RefSeq protein accession numbers for the human NPC1L1 gene are NP_001095118, NP_001287896, and NP_037521.

NPC1L1 expression in the testicle suggests a role solely related to cholesterol absorption.

Answer: False

Expression data in tissues like the testicle suggests that NPC1L1 may have functions beyond cholesterol absorption, potentially related to specific tissue physiology.

Related Concepts:

  • What does the presence of NPC1L1 in the testicle suggest about its potential roles?: The expression of NPC1L1 RNA in the testicle, as indicated by Bgee data, suggests potential roles beyond cholesterol absorption, possibly related to testicular function or development.
  • What is the significance of NPC1L1's involvement in 'intestinal cholesterol absorption' as indicated by its Gene Ontology classification?: The classification of NPC1L1 in processes like 'intestinal cholesterol absorption' directly links it to the mechanism by which the body takes up dietary cholesterol from the digestive system, highlighting its importance in lipid homeostasis.
  • What key biological processes is NPC1L1 involved in, as categorized by the Gene Ontology?: Gene Ontology categorizes NPC1L1 as being involved in biological processes such as lipoprotein metabolic process, steroid metabolic process, lipid metabolism, cholesterol transport, cholesterol metabolic process, intestinal cholesterol absorption, cholesterol biosynthetic process, intestinal lipid absorption, and cellular response to sterol depletion.

Where is the NPC1L1 protein primarily expressed in the human body?

Answer: Epithelial cells of the gastrointestinal tract and hepatocytes

The NPC1L1 protein is primarily expressed in the epithelial cells of the gastrointestinal tract and in hepatocytes.

Related Concepts:

  • According to expression data from Bgee, in which human tissues does NPC1L1 exhibit the highest levels of RNA expression?: According to Bgee data, NPC1L1 RNA shows high expression in human tissues including the jejunal mucosa, duodenum, right lobe of the liver, testicles, islet of Langerhans, gallbladder, muscle layer of the sigmoid colon, right coronary artery, descending thoracic aorta, and popliteal artery.
  • What are the primary anatomical locations of NPC1L1 protein expression in the human body?: The NPC1L1 protein is predominantly expressed in the epithelial cells lining the gastrointestinal tract and within hepatocytes, the principal functional cells of the liver.
  • What is the significance of the NPC1L1 protein's presence on the brush border membrane?: The Gene Ontology lists NPC1L1 as being associated with the brush border membrane, which is a characteristic feature of cells lining the small intestine, suggesting a role in absorption processes occurring there.

According to Bgee data, which mouse tissue shows significant NPC1L1 RNA expression?

Answer: Epithelium of the small intestine

Bgee data indicates significant NPC1L1 RNA expression in the epithelium of the small intestine in mice, among other tissues.

Related Concepts:

  • Based on Bgee data, what are the primary mouse tissues demonstrating significant NPC1L1 RNA expression?: Bgee data indicates that NPC1L1 RNA is highly expressed in mouse tissues such as the epithelium of the small intestine, jejunum, ileum, duodenum, migratory enteric neural crest cells, embryos, Paneth cells, morulae, blastocysts, and the yolk sac.
  • According to expression data from Bgee, in which human tissues does NPC1L1 exhibit the highest levels of RNA expression?: According to Bgee data, NPC1L1 RNA shows high expression in human tissues including the jejunal mucosa, duodenum, right lobe of the liver, testicles, islet of Langerhans, gallbladder, muscle layer of the sigmoid colon, right coronary artery, descending thoracic aorta, and popliteal artery.
  • What does the presence of NPC1L1 in the testicle suggest about its potential roles?: The expression of NPC1L1 RNA in the testicle, as indicated by Bgee data, suggests potential roles beyond cholesterol absorption, possibly related to testicular function or development.

Which molecular function is assigned to NPC1L1 by the Gene Ontology?

Answer: Myosin V binding

Gene Ontology assigns molecular functions such as myosin V binding and protein binding to NPC1L1.

Related Concepts:

  • What key biological processes is NPC1L1 involved in, as categorized by the Gene Ontology?: Gene Ontology categorizes NPC1L1 as being involved in biological processes such as lipoprotein metabolic process, steroid metabolic process, lipid metabolism, cholesterol transport, cholesterol metabolic process, intestinal cholesterol absorption, cholesterol biosynthetic process, intestinal lipid absorption, and cellular response to sterol depletion.
  • How is NPC1L1 related to lipid metabolism according to its Gene Ontology classification?: According to Gene Ontology, NPC1L1 is involved in several lipid metabolism-related processes, including lipoprotein metabolic process, steroid metabolic process, lipid metabolism, cholesterol transport, cholesterol metabolic process, and cholesterol biosynthetic process.
  • In terms of cellular localization, what components does the Gene Ontology identify as being associated with NPC1L1?: The Gene Ontology identifies NPC1L1 as being associated with the membrane, plasma membrane, brush border membrane, apical plasma membrane, cytoplasmic vesicle membrane, cytoplasmic vesicle, integral component of membrane, and spanning component of plasma membrane.

Which cellular component is NPC1L1 associated with, according to Gene Ontology?

Answer: Brush border membrane

Gene Ontology associates NPC1L1 with cellular components including the brush border membrane, plasma membrane, and integral components of membranes.

Related Concepts:

  • In terms of cellular localization, what components does the Gene Ontology identify as being associated with NPC1L1?: The Gene Ontology identifies NPC1L1 as being associated with the membrane, plasma membrane, brush border membrane, apical plasma membrane, cytoplasmic vesicle membrane, cytoplasmic vesicle, integral component of membrane, and spanning component of plasma membrane.
  • What key biological processes is NPC1L1 involved in, as categorized by the Gene Ontology?: Gene Ontology categorizes NPC1L1 as being involved in biological processes such as lipoprotein metabolic process, steroid metabolic process, lipid metabolism, cholesterol transport, cholesterol metabolic process, intestinal cholesterol absorption, cholesterol biosynthetic process, intestinal lipid absorption, and cellular response to sterol depletion.
  • What is the significance of the NPC1L1 protein's presence on the brush border membrane?: The Gene Ontology lists NPC1L1 as being associated with the brush border membrane, which is a characteristic feature of cells lining the small intestine, suggesting a role in absorption processes occurring there.

The association of NPC1L1 with the 'apical plasma membrane' suggests its role in:

Answer: Transport across the cell surface facing the lumen

Localization to the apical plasma membrane, particularly in intestinal cells, indicates a role in transport processes occurring at the luminal surface.

Related Concepts:

  • In terms of cellular localization, what components does the Gene Ontology identify as being associated with NPC1L1?: The Gene Ontology identifies NPC1L1 as being associated with the membrane, plasma membrane, brush border membrane, apical plasma membrane, cytoplasmic vesicle membrane, cytoplasmic vesicle, integral component of membrane, and spanning component of plasma membrane.
  • What is the significance of NPC1L1 being located on the plasma membrane?: NPC1L1's presence on the plasma membrane, the outer boundary of the cell, is crucial for its function in interacting with substances from the extracellular environment, such as cholesterol or viruses.
  • What is the functional relevance of NPC1L1 being an 'integral component of membrane'?: Being an integral component of the membrane means that NPC1L1 is embedded within the cell's lipid bilayer, which is essential for its function as a receptor or transporter that interacts with molecules across the membrane boundary.

NPC1L1: Cholesterol Metabolism and Absorption

NPC1L1 plays a direct role in facilitating the absorption of cholesterol from the digestive system.

Answer: True

NPC1L1 is recognized as a critical protein mediating the absorption of dietary cholesterol from the intestinal lumen into enterocytes.

Related Concepts:

  • What role does the NPC1L1 protein play in the biological process of cholesterol absorption?: The NPC1L1 protein appears to bind to a critical mediator that is essential for the absorption of cholesterol from the digestive system into the body.
  • What is the significance of NPC1L1's involvement in 'intestinal cholesterol absorption' as indicated by its Gene Ontology classification?: The classification of NPC1L1 in processes like 'intestinal cholesterol absorption' directly links it to the mechanism by which the body takes up dietary cholesterol from the digestive system, highlighting its importance in lipid homeostasis.
  • What key biological processes is NPC1L1 involved in, as categorized by the Gene Ontology?: Gene Ontology categorizes NPC1L1 as being involved in biological processes such as lipoprotein metabolic process, steroid metabolic process, lipid metabolism, cholesterol transport, cholesterol metabolic process, intestinal cholesterol absorption, cholesterol biosynthetic process, intestinal lipid absorption, and cellular response to sterol depletion.

The Gene Ontology classifies NPC1L1 as being involved in steroid metabolic processes.

Answer: True

Gene Ontology annotations confirm NPC1L1's involvement in steroid metabolic processes, among other lipid-related biological processes.

Related Concepts:

  • What key biological processes is NPC1L1 involved in, as categorized by the Gene Ontology?: Gene Ontology categorizes NPC1L1 as being involved in biological processes such as lipoprotein metabolic process, steroid metabolic process, lipid metabolism, cholesterol transport, cholesterol metabolic process, intestinal cholesterol absorption, cholesterol biosynthetic process, intestinal lipid absorption, and cellular response to sterol depletion.
  • How is NPC1L1 related to lipid metabolism according to its Gene Ontology classification?: According to Gene Ontology, NPC1L1 is involved in several lipid metabolism-related processes, including lipoprotein metabolic process, steroid metabolic process, lipid metabolism, cholesterol transport, cholesterol metabolic process, and cholesterol biosynthetic process.
  • What is the significance of NPC1L1's involvement in 'intestinal cholesterol absorption' as indicated by its Gene Ontology classification?: The classification of NPC1L1 in processes like 'intestinal cholesterol absorption' directly links it to the mechanism by which the body takes up dietary cholesterol from the digestive system, highlighting its importance in lipid homeostasis.

NPC1L1's presence in hepatocytes is irrelevant to its role in cholesterol metabolism.

Answer: False

The presence of NPC1L1 in hepatocytes is highly relevant, as the liver plays a central role in processing cholesterol absorbed from the intestine and regulating systemic cholesterol homeostasis.

Related Concepts:

  • How does the location of NPC1L1 in hepatocytes relate to its function?: The presence of NPC1L1 in hepatocytes, the main cells of the liver, is significant because the liver plays a crucial role in cholesterol metabolism and processing absorbed cholesterol from the gastrointestinal tract.
  • How is NPC1L1 related to lipid metabolism according to its Gene Ontology classification?: According to Gene Ontology, NPC1L1 is involved in several lipid metabolism-related processes, including lipoprotein metabolic process, steroid metabolic process, lipid metabolism, cholesterol transport, cholesterol metabolic process, and cholesterol biosynthetic process.
  • What key biological processes is NPC1L1 involved in, as categorized by the Gene Ontology?: Gene Ontology categorizes NPC1L1 as being involved in biological processes such as lipoprotein metabolic process, steroid metabolic process, lipid metabolism, cholesterol transport, cholesterol metabolic process, intestinal cholesterol absorption, cholesterol biosynthetic process, intestinal lipid absorption, and cellular response to sterol depletion.

NPC1L1's role in 'intestinal cholesterol absorption' is a key aspect of its function.

Answer: True

The classification of NPC1L1 within processes like 'intestinal cholesterol absorption' highlights its fundamental role in mediating the uptake of dietary cholesterol.

Related Concepts:

  • What is the significance of NPC1L1's involvement in 'intestinal cholesterol absorption' as indicated by its Gene Ontology classification?: The classification of NPC1L1 in processes like 'intestinal cholesterol absorption' directly links it to the mechanism by which the body takes up dietary cholesterol from the digestive system, highlighting its importance in lipid homeostasis.
  • What role does the NPC1L1 protein play in the biological process of cholesterol absorption?: The NPC1L1 protein appears to bind to a critical mediator that is essential for the absorption of cholesterol from the digestive system into the body.
  • What key biological processes is NPC1L1 involved in, as categorized by the Gene Ontology?: Gene Ontology categorizes NPC1L1 as being involved in biological processes such as lipoprotein metabolic process, steroid metabolic process, lipid metabolism, cholesterol transport, cholesterol metabolic process, intestinal cholesterol absorption, cholesterol biosynthetic process, intestinal lipid absorption, and cellular response to sterol depletion.

NPC1L1 is involved in cholesterol biosynthesis according to Gene Ontology.

Answer: True

Gene Ontology annotations include cholesterol biosynthetic process as one of the biological processes NPC1L1 is involved in.

Related Concepts:

  • How is NPC1L1 related to lipid metabolism according to its Gene Ontology classification?: According to Gene Ontology, NPC1L1 is involved in several lipid metabolism-related processes, including lipoprotein metabolic process, steroid metabolic process, lipid metabolism, cholesterol transport, cholesterol metabolic process, and cholesterol biosynthetic process.
  • What key biological processes is NPC1L1 involved in, as categorized by the Gene Ontology?: Gene Ontology categorizes NPC1L1 as being involved in biological processes such as lipoprotein metabolic process, steroid metabolic process, lipid metabolism, cholesterol transport, cholesterol metabolic process, intestinal cholesterol absorption, cholesterol biosynthetic process, intestinal lipid absorption, and cellular response to sterol depletion.
  • What is the significance of NPC1L1's involvement in 'intestinal cholesterol absorption' as indicated by its Gene Ontology classification?: The classification of NPC1L1 in processes like 'intestinal cholesterol absorption' directly links it to the mechanism by which the body takes up dietary cholesterol from the digestive system, highlighting its importance in lipid homeostasis.

What is the main function of NPC1L1 related to cholesterol?

Answer: Facilitating cholesterol absorption from the digestive system

The primary function of NPC1L1 is to facilitate the absorption of cholesterol from the digestive tract into the body.

Related Concepts:

  • What key biological processes is NPC1L1 involved in, as categorized by the Gene Ontology?: Gene Ontology categorizes NPC1L1 as being involved in biological processes such as lipoprotein metabolic process, steroid metabolic process, lipid metabolism, cholesterol transport, cholesterol metabolic process, intestinal cholesterol absorption, cholesterol biosynthetic process, intestinal lipid absorption, and cellular response to sterol depletion.
  • How is NPC1L1 related to lipid metabolism according to its Gene Ontology classification?: According to Gene Ontology, NPC1L1 is involved in several lipid metabolism-related processes, including lipoprotein metabolic process, steroid metabolic process, lipid metabolism, cholesterol transport, cholesterol metabolic process, and cholesterol biosynthetic process.
  • What role does the NPC1L1 protein play in the biological process of cholesterol absorption?: The NPC1L1 protein appears to bind to a critical mediator that is essential for the absorption of cholesterol from the digestive system into the body.

Which biological process, related to lipids, is NPC1L1 involved in according to Gene Ontology?

Answer: Lipoprotein metabolic process

Gene Ontology classifies NPC1L1 as involved in processes such as lipoprotein metabolic process, steroid metabolic process, and cholesterol transport.

Related Concepts:

  • What key biological processes is NPC1L1 involved in, as categorized by the Gene Ontology?: Gene Ontology categorizes NPC1L1 as being involved in biological processes such as lipoprotein metabolic process, steroid metabolic process, lipid metabolism, cholesterol transport, cholesterol metabolic process, intestinal cholesterol absorption, cholesterol biosynthetic process, intestinal lipid absorption, and cellular response to sterol depletion.
  • How is NPC1L1 related to lipid metabolism according to its Gene Ontology classification?: According to Gene Ontology, NPC1L1 is involved in several lipid metabolism-related processes, including lipoprotein metabolic process, steroid metabolic process, lipid metabolism, cholesterol transport, cholesterol metabolic process, and cholesterol biosynthetic process.
  • What is the significance of NPC1L1's involvement in 'intestinal cholesterol absorption' as indicated by its Gene Ontology classification?: The classification of NPC1L1 in processes like 'intestinal cholesterol absorption' directly links it to the mechanism by which the body takes up dietary cholesterol from the digestive system, highlighting its importance in lipid homeostasis.

What is the primary implication of NPC1L1 being involved in 'intestinal cholesterol absorption'?

Answer: It is essential for the uptake of dietary cholesterol.

Involvement in 'intestinal cholesterol absorption' signifies that NPC1L1 is crucial for the process by which dietary cholesterol is taken up from the gut.

Related Concepts:

  • What is the significance of NPC1L1's involvement in 'intestinal cholesterol absorption' as indicated by its Gene Ontology classification?: The classification of NPC1L1 in processes like 'intestinal cholesterol absorption' directly links it to the mechanism by which the body takes up dietary cholesterol from the digestive system, highlighting its importance in lipid homeostasis.
  • What role does the NPC1L1 protein play in the biological process of cholesterol absorption?: The NPC1L1 protein appears to bind to a critical mediator that is essential for the absorption of cholesterol from the digestive system into the body.
  • What key biological processes is NPC1L1 involved in, as categorized by the Gene Ontology?: Gene Ontology categorizes NPC1L1 as being involved in biological processes such as lipoprotein metabolic process, steroid metabolic process, lipid metabolism, cholesterol transport, cholesterol metabolic process, intestinal cholesterol absorption, cholesterol biosynthetic process, intestinal lipid absorption, and cellular response to sterol depletion.

NPC1L1: Pharmacology and Therapeutic Applications

The medication ezetimibe enhances the function of the NPC1L1 protein.

Answer: False

Ezetimibe functions as an inhibitor of the NPC1L1 protein, thereby reducing cholesterol absorption.

Related Concepts:

  • How does the medication ezetimibe interact with the NPC1L1 protein?: The medication ezetimibe functions by inhibiting the NPC1L1 protein.
  • What are the quantitative effects on blood cholesterol levels when NPC1L1 is inhibited by ezetimibe?: When ezetimibe inhibits NPC1L1, it leads to a reduction in cholesterol absorption, consequently causing a decrease in blood cholesterol levels by approximately 15% to 20%.
  • What is the relationship between NPC1L1 and the drug ezetimibe regarding cholesterol reduction?: Ezetimibe inhibits NPC1L1, which in turn reduces cholesterol absorption in the intestine, leading to lower blood cholesterol levels.

Inhibition of NPC1L1 by ezetimibe typically reduces blood cholesterol levels by about 5% to 10%.

Answer: False

The inhibition of NPC1L1 by ezetimibe typically results in a reduction of blood cholesterol levels by approximately 15% to 20%.

Related Concepts:

  • What are the quantitative effects on blood cholesterol levels when NPC1L1 is inhibited by ezetimibe?: When ezetimibe inhibits NPC1L1, it leads to a reduction in cholesterol absorption, consequently causing a decrease in blood cholesterol levels by approximately 15% to 20%.
  • What is the relationship between NPC1L1 and the drug ezetimibe regarding cholesterol reduction?: Ezetimibe inhibits NPC1L1, which in turn reduces cholesterol absorption in the intestine, leading to lower blood cholesterol levels.
  • How does the medication ezetimibe interact with the NPC1L1 protein?: The medication ezetimibe functions by inhibiting the NPC1L1 protein.

NPC1L1 is identified as a key factor in the cellular entry mechanism of the Hepatitis C Virus.

Answer: True

Research indicates that NPC1L1 functions as an accessory receptor, facilitating the entry of the Hepatitis C Virus into host cells.

Related Concepts:

  • How is NPC1L1 implicated in the cellular entry mechanism of the Hepatitis C Virus?: NPC1L1 has been identified as an accessory receptor that facilitates the entry of the Hepatitis C virus into host cells.
  • What is the potential therapeutic implication of NPC1L1's role as an entry factor for Hepatitis C Virus?: Since NPC1L1 acts as an accessory receptor for Hepatitis C Virus entry, inhibiting NPC1L1, potentially with drugs like ezetimibe, could be explored as a therapeutic strategy to combat HCV infection.
  • What is the significance of NPC1L1 being located on the plasma membrane?: NPC1L1's presence on the plasma membrane, the outer boundary of the cell, is crucial for its function in interacting with substances from the extracellular environment, such as cholesterol or viruses.

A comprehensive meta-analysis confirmed an increased risk of cancer in patients treated with ezetimibe.

Answer: False

Subsequent comprehensive meta-analyses have concluded that there is no observed increase in cancer risk associated with ezetimibe treatment.

Related Concepts:

  • Following initial concerns, what did a comprehensive meta-analysis reveal about the association between ezetimibe treatment and cancer incidence?: A meta-analysis that reviewed clinical data related to ezetimibe treatment concluded that there was no observed increase in the risk of cancer associated with using the drug.
  • What concern was raised regarding a potential link between NPC1L1 inhibition and cancer risk, and on what basis?: A concern was raised that NPC1L1 inhibition by ezetimibe might be associated with an increased risk of cancer. This hypothesis stemmed from observations in one clinical trial where cancer incidence appeared higher in patients receiving a combination therapy of simvastatin and ezetimibe.

Inhibiting NPC1L1 is being explored as a strategy against Hepatitis C Virus infection.

Answer: True

Given NPC1L1's role as an entry factor for HCV, its inhibition is indeed being investigated as a potential therapeutic approach for HCV infection.

Related Concepts:

  • What is the potential therapeutic implication of NPC1L1's role as an entry factor for Hepatitis C Virus?: Since NPC1L1 acts as an accessory receptor for Hepatitis C Virus entry, inhibiting NPC1L1, potentially with drugs like ezetimibe, could be explored as a therapeutic strategy to combat HCV infection.
  • How is NPC1L1 implicated in the cellular entry mechanism of the Hepatitis C Virus?: NPC1L1 has been identified as an accessory receptor that facilitates the entry of the Hepatitis C virus into host cells.

How does the drug ezetimibe affect NPC1L1?

Answer: It inhibits the function of NPC1L1.

Ezetimibe functions by inhibiting the activity of the NPC1L1 protein.

Related Concepts:

  • How does the medication ezetimibe interact with the NPC1L1 protein?: The medication ezetimibe functions by inhibiting the NPC1L1 protein.
  • What are the quantitative effects on blood cholesterol levels when NPC1L1 is inhibited by ezetimibe?: When ezetimibe inhibits NPC1L1, it leads to a reduction in cholesterol absorption, consequently causing a decrease in blood cholesterol levels by approximately 15% to 20%.
  • What is the relationship between NPC1L1 and the drug ezetimibe regarding cholesterol reduction?: Ezetimibe inhibits NPC1L1, which in turn reduces cholesterol absorption in the intestine, leading to lower blood cholesterol levels.

What is the approximate percentage decrease in blood cholesterol levels observed when ezetimibe inhibits NPC1L1?

Answer: 15% to 20%

Inhibition of NPC1L1 by ezetimibe typically leads to a reduction in blood cholesterol levels ranging from approximately 15% to 20%.

Related Concepts:

  • What are the quantitative effects on blood cholesterol levels when NPC1L1 is inhibited by ezetimibe?: When ezetimibe inhibits NPC1L1, it leads to a reduction in cholesterol absorption, consequently causing a decrease in blood cholesterol levels by approximately 15% to 20%.
  • What is the relationship between NPC1L1 and the drug ezetimibe regarding cholesterol reduction?: Ezetimibe inhibits NPC1L1, which in turn reduces cholesterol absorption in the intestine, leading to lower blood cholesterol levels.
  • How does the medication ezetimibe interact with the NPC1L1 protein?: The medication ezetimibe functions by inhibiting the NPC1L1 protein.

NPC1L1 serves as an accessory receptor for the cellular entry of which virus?

Answer: Hepatitis C Virus (HCV)

NPC1L1 acts as an accessory receptor that facilitates the entry of the Hepatitis C Virus into host cells.

Related Concepts:

  • How is NPC1L1 implicated in the cellular entry mechanism of the Hepatitis C Virus?: NPC1L1 has been identified as an accessory receptor that facilitates the entry of the Hepatitis C virus into host cells.
  • What is the potential therapeutic implication of NPC1L1's role as an entry factor for Hepatitis C Virus?: Since NPC1L1 acts as an accessory receptor for Hepatitis C Virus entry, inhibiting NPC1L1, potentially with drugs like ezetimibe, could be explored as a therapeutic strategy to combat HCV infection.

Initial concerns about NPC1L1 inhibition by ezetimibe were related to a potential increase in:

Answer: Cancer risk

Early hypotheses suggested a potential link between NPC1L1 inhibition by ezetimibe and an increased risk of cancer, based on observations from certain clinical trials.

Related Concepts:

  • What concern was raised regarding a potential link between NPC1L1 inhibition and cancer risk, and on what basis?: A concern was raised that NPC1L1 inhibition by ezetimibe might be associated with an increased risk of cancer. This hypothesis stemmed from observations in one clinical trial where cancer incidence appeared higher in patients receiving a combination therapy of simvastatin and ezetimibe.
  • What are the quantitative effects on blood cholesterol levels when NPC1L1 is inhibited by ezetimibe?: When ezetimibe inhibits NPC1L1, it leads to a reduction in cholesterol absorption, consequently causing a decrease in blood cholesterol levels by approximately 15% to 20%.
  • How does the medication ezetimibe interact with the NPC1L1 protein?: The medication ezetimibe functions by inhibiting the NPC1L1 protein.

What did a subsequent meta-analysis conclude regarding ezetimibe treatment and cancer incidence?

Answer: It found no observed increase in cancer risk.

A comprehensive meta-analysis examining data from ezetimibe treatments found no evidence of an increased cancer risk.

Related Concepts:

  • Following initial concerns, what did a comprehensive meta-analysis reveal about the association between ezetimibe treatment and cancer incidence?: A meta-analysis that reviewed clinical data related to ezetimibe treatment concluded that there was no observed increase in the risk of cancer associated with using the drug.
  • What concern was raised regarding a potential link between NPC1L1 inhibition and cancer risk, and on what basis?: A concern was raised that NPC1L1 inhibition by ezetimibe might be associated with an increased risk of cancer. This hypothesis stemmed from observations in one clinical trial where cancer incidence appeared higher in patients receiving a combination therapy of simvastatin and ezetimibe.

NPC1L1: Genetics and Disease Association

Genetic variations within the NPC1L1 gene have no known impact on how patients respond to ezetimibe.

Answer: False

Polymorphisms in the NPC1L1 gene can influence patient response to ezetimibe, potentially leading to differential efficacy.

Related Concepts:

  • What is the potential impact of genetic variations within the NPC1L1 gene on an individual's response to ezetimibe therapy?: Polymorphic variations, or differences in the DNA sequence, within the NPC1L1 gene could be associated with individuals not responding effectively to ezetimibe treatment.
  • How does the medication ezetimibe interact with the NPC1L1 protein?: The medication ezetimibe functions by inhibiting the NPC1L1 protein.
  • What are the quantitative effects on blood cholesterol levels when NPC1L1 is inhibited by ezetimibe?: When ezetimibe inhibits NPC1L1, it leads to a reduction in cholesterol absorption, consequently causing a decrease in blood cholesterol levels by approximately 15% to 20%.

Individuals with inactivating mutations in the NPC1L1 gene exhibit an increased risk for coronary heart disease.

Answer: False

Conversely, individuals with inactivating NPC1L1 mutations demonstrate a significantly reduced risk for coronary heart disease, associated with lower LDL cholesterol levels.

Related Concepts:

  • Beyond cholesterol levels, what significant health risks appear to be reduced in individuals with inactivating NPC1L1 gene mutations?: Individuals possessing inactivating mutations in the NPC1L1 gene have been observed to have lower levels of LDL cholesterol and approximately a 50% reduction in their risk of developing coronary heart disease.
  • How is NPC1L1 related to lipid metabolism according to its Gene Ontology classification?: According to Gene Ontology, NPC1L1 is involved in several lipid metabolism-related processes, including lipoprotein metabolic process, steroid metabolic process, lipid metabolism, cholesterol transport, cholesterol metabolic process, and cholesterol biosynthetic process.
  • What key biological processes is NPC1L1 involved in, as categorized by the Gene Ontology?: Gene Ontology categorizes NPC1L1 as being involved in biological processes such as lipoprotein metabolic process, steroid metabolic process, lipid metabolism, cholesterol transport, cholesterol metabolic process, intestinal cholesterol absorption, cholesterol biosynthetic process, intestinal lipid absorption, and cellular response to sterol depletion.

The NPC1L1 gene is located on Chromosome 7 in mice.

Answer: False

In mice, the NPC1L1 gene is located on Chromosome 11, not Chromosome 7.

Related Concepts:

  • How does the chromosomal location of the NPC1L1 gene differ between humans and mice?: In humans, the NPC1L1 gene is found on Chromosome 7 at band 7p13, whereas in mice, it is located on Chromosome 11 at band 11A1.
  • What are the genomic coordinates for the NPC1L1 gene in mice, corresponding to its location on Chromosome 11?: The NPC1L1 gene in mice is situated on Chromosome 11 between base pair 6,161,013 and 6,180,143.
  • Could you specify the chromosomal location, including the band, of the NPC1L1 gene in humans?: In humans, the NPC1L1 gene is located on Chromosome 7, specifically within the 7p13 band.

The designation 'Niemann-Pick C1-Like 1' implies no relationship to Niemann-Pick disease.

Answer: False

The name 'Niemann-Pick C1-Like 1' explicitly suggests a relationship or similarity to the protein involved in Niemann-Pick disease type C1, implying a shared role in lipid metabolism or transport.

Related Concepts:

  • What is the complete designation for the protein commonly referred to as NPC1L1?: The complete designation for the protein commonly referred to as NPC1L1 is Niemann-Pick C1-Like 1.
  • What does the term 'Niemann-Pick C1-Like 1' suggest about the protein's relationship to other known conditions or proteins?: The name 'Niemann-Pick C1-Like 1' suggests that this protein shares similarities or a functional relationship with the protein involved in Niemann-Pick disease type C1, indicating a potential role in lipid metabolism or transport.

Which health condition shows a significantly reduced risk (around 50%) in individuals with inactivating NPC1L1 gene mutations?

Answer: Coronary Heart Disease

Individuals with inactivating mutations in the NPC1L1 gene exhibit approximately a 50% reduction in their risk of developing coronary heart disease.

Related Concepts:

  • Beyond cholesterol levels, what significant health risks appear to be reduced in individuals with inactivating NPC1L1 gene mutations?: Individuals possessing inactivating mutations in the NPC1L1 gene have been observed to have lower levels of LDL cholesterol and approximately a 50% reduction in their risk of developing coronary heart disease.

In the human genome, the NPC1L1 gene is located on Chromosome 7 at which band?

Answer: 7p13

The NPC1L1 gene in the human genome is located on Chromosome 7 at the 7p13 band.

Related Concepts:

  • Could you specify the chromosomal location, including the band, of the NPC1L1 gene in humans?: In humans, the NPC1L1 gene is located on Chromosome 7, specifically within the 7p13 band.
  • What are the precise genomic coordinates (start and end base pairs) for the NPC1L1 gene on human Chromosome 7?: The NPC1L1 gene on human Chromosome 7 spans from base pair 44,512,535 to 44,541,330.
  • How does the chromosomal location of the NPC1L1 gene differ between humans and mice?: In humans, the NPC1L1 gene is found on Chromosome 7 at band 7p13, whereas in mice, it is located on Chromosome 11 at band 11A1.

What are the genomic coordinates for the NPC1L1 gene in humans?

Answer: 44,512,535 to 44,541,330

The genomic coordinates for the NPC1L1 gene in humans span from base pair 44,512,535 to 44,541,330 on Chromosome 7.

Related Concepts:

  • What are the precise genomic coordinates (start and end base pairs) for the NPC1L1 gene on human Chromosome 7?: The NPC1L1 gene on human Chromosome 7 spans from base pair 44,512,535 to 44,541,330.
  • What are the RefSeq protein accession numbers corresponding to the human NPC1L1 gene?: The RefSeq protein accession numbers for the human NPC1L1 gene are NP_001095118, NP_001287896, and NP_037521.
  • Could you specify the chromosomal location, including the band, of the NPC1L1 gene in humans?: In humans, the NPC1L1 gene is located on Chromosome 7, specifically within the 7p13 band.

The chromosomal location of NPC1L1 in humans is 7p13, while in mice it is located on:

Answer: Chromosome 11, band 11A1

While human NPC1L1 is on Chromosome 7p13, the mouse NPC1L1 gene is located on Chromosome 11, specifically band 11A1.

Related Concepts:

  • How does the chromosomal location of the NPC1L1 gene differ between humans and mice?: In humans, the NPC1L1 gene is found on Chromosome 7 at band 7p13, whereas in mice, it is located on Chromosome 11 at band 11A1.
  • What are the genomic coordinates for the NPC1L1 gene in mice, corresponding to its location on Chromosome 11?: The NPC1L1 gene in mice is situated on Chromosome 11 between base pair 6,161,013 and 6,180,143.
  • Could you specify the chromosomal location, including the band, of the NPC1L1 gene in humans?: In humans, the NPC1L1 gene is located on Chromosome 7, specifically within the 7p13 band.

NPC1L1: Bioinformatics and Database Identifiers

The symbol SLC65A2 serves as an alternative designation for the NPC1L1 protein.

Answer: True

SLC65A2 is indeed one of the alternative symbols or names used to refer to the NPC1L1 protein.

Related Concepts:

  • Beyond its primary designation, what other names or symbols are used to refer to NPC1L1?: Other names and symbols used for NPC1L1 include NPC11L1, NPC1 like intracellular cholesterol transporter 1, SLC65A2, and LDLCQ7.
  • What is the complete designation for the protein commonly referred to as NPC1L1?: The complete designation for the protein commonly referred to as NPC1L1 is Niemann-Pick C1-Like 1.
  • What are the respective UniProt accession numbers for the NPC1L1 protein in humans and mice?: The UniProt accession number for human NPC1L1 is Q9UHC9, and for mouse NPC1L1, it is Q6T3U4.

The UniProt accession number for human NPC1L1 is Q6T3U4.

Answer: False

The UniProt accession number for human NPC1L1 is Q9UHC9; Q6T3U4 corresponds to mouse NPC1L1.

Related Concepts:

  • What are the respective UniProt accession numbers for the NPC1L1 protein in humans and mice?: The UniProt accession number for human NPC1L1 is Q9UHC9, and for mouse NPC1L1, it is Q6T3U4.
  • What are the RefSeq protein accession numbers corresponding to the human NPC1L1 gene?: The RefSeq protein accession numbers for the human NPC1L1 gene are NP_001095118, NP_001287896, and NP_037521.
  • What are the various RefSeq mRNA accession numbers associated with the human NPC1L1 gene?: The human NPC1L1 gene is associated with the RefSeq mRNA accession numbers NM_001101648, NM_001300967, and NM_013389.

The Ensembl gene identifier for mouse NPC1L1 is ENSMUSG00000020447.

Answer: False

ENSMUSG00000020447 is the Ensembl gene identifier for human NPC1L1, not mouse NPC1L1.

Related Concepts:

  • Can you provide the Ensembl gene identifiers for NPC1L1 in both human and mouse genomes?: The Ensembl gene identifier for human NPC1L1 is ENSG00000015520, and for mouse NPC1L1, it is ENSMUSG00000020447.
  • What are the Entrez gene identification numbers for NPC1L1 in humans and mice?: The Entrez gene ID for human NPC1L1 is 29881, and for mouse NPC1L1, it is 237636.
  • What are the various RefSeq mRNA accession numbers associated with the human NPC1L1 gene?: The human NPC1L1 gene is associated with the RefSeq mRNA accession numbers NM_001101648, NM_001300967, and NM_013389.

The Entrez gene ID for human NPC1L1 is 237636.

Answer: False

The Entrez gene ID for human NPC1L1 is 29881; 237636 is the Entrez ID for mouse NPC1L1.

Related Concepts:

  • What are the Entrez gene identification numbers for NPC1L1 in humans and mice?: The Entrez gene ID for human NPC1L1 is 29881, and for mouse NPC1L1, it is 237636.
  • What are the RefSeq protein accession numbers corresponding to the human NPC1L1 gene?: The RefSeq protein accession numbers for the human NPC1L1 gene are NP_001095118, NP_001287896, and NP_037521.
  • Can you provide the Ensembl gene identifiers for NPC1L1 in both human and mouse genomes?: The Ensembl gene identifier for human NPC1L1 is ENSG00000015520, and for mouse NPC1L1, it is ENSMUSG00000020447.

There are no listed RefSeq protein accession numbers for the human NPC1L1 gene in the provided text.

Answer: False

The provided text lists several RefSeq protein accession numbers for the human NPC1L1 gene, including NP_001095118, NP_001287896, and NP_037521.

Related Concepts:

  • What are the RefSeq protein accession numbers corresponding to the human NPC1L1 gene?: The RefSeq protein accession numbers for the human NPC1L1 gene are NP_001095118, NP_001287896, and NP_037521.
  • Does the provided text include a RefSeq protein identifier for the mouse NPC1L1?: No, the provided text indicates that there is no RefSeq protein identifier listed for mouse NPC1L1 (marked as n/a).
  • What are the various RefSeq mRNA accession numbers associated with the human NPC1L1 gene?: The human NPC1L1 gene is associated with the RefSeq mRNA accession numbers NM_001101648, NM_001300967, and NM_013389.

The Protein Data Bank (PDB) identifier 3QNT is associated with NPC1L1 structures.

Answer: True

The identifier 3QNT is indeed referenced in relation to Protein Data Bank (PDB) structures concerning NPC1L1.

Related Concepts:

  • What specific identifier is referenced in the context of Protein Data Bank (PDB) structures related to NPC1L1?: The identifier 3QNT is referenced in the context of Protein Data Bank (PDB) structures related to NPC1L1.
  • Which external links provide access to structural information for NPC1L1?: The PDBe-KB database provides access to structural information for human NPC1L1 (UniProt Q9UHC9).
  • What are the respective UniProt accession numbers for the NPC1L1 protein in humans and mice?: The UniProt accession number for human NPC1L1 is Q9UHC9, and for mouse NPC1L1, it is Q6T3U4.

Multiple RefSeq mRNA identifiers for human NPC1L1 suggest only one functional transcript variant exists.

Answer: False

The existence of multiple RefSeq mRNA identifiers typically indicates the presence of different transcript variants or isoforms, potentially leading to diverse protein products.

Related Concepts:

  • What does the presence of multiple RefSeq mRNA identifiers for human NPC1L1 suggest?: The existence of multiple RefSeq mRNA identifiers for human NPC1L1 suggests that there might be different transcript variants or isoforms of the gene, potentially leading to proteins with slightly different functions or expression patterns.
  • What are the various RefSeq mRNA accession numbers associated with the human NPC1L1 gene?: The human NPC1L1 gene is associated with the RefSeq mRNA accession numbers NM_001101648, NM_001300967, and NM_013389.
  • What are the RefSeq protein accession numbers corresponding to the human NPC1L1 gene?: The RefSeq protein accession numbers for the human NPC1L1 gene are NP_001095118, NP_001287896, and NP_037521.

The PDBe-KB database provides access to structural information for mouse NPC1L1.

Answer: False

The PDBe-KB database provides access to structural information for human NPC1L1, not mouse NPC1L1.

Related Concepts:

  • Which external links provide access to structural information for NPC1L1?: The PDBe-KB database provides access to structural information for human NPC1L1 (UniProt Q9UHC9).
  • Beyond standard gene and protein databases, what other external resources offer information or related media for NPC1L1?: External resources offering information on NPC1L1 include the U.S. National Library of Medicine's Medical Subject Headings (MeSH), the PDBe-KB database, Wikidata, and Wikimedia Commons, which hosts related media.
  • What are the respective UniProt accession numbers for the NPC1L1 protein in humans and mice?: The UniProt accession number for human NPC1L1 is Q9UHC9, and for mouse NPC1L1, it is Q6T3U4.

What is the full designation for the protein commonly abbreviated as NPC1L1?

Answer: Niemann-Pick C1-Like 1

The full designation for the protein commonly abbreviated as NPC1L1 is Niemann-Pick C1-Like 1.

Related Concepts:

  • What is the complete designation for the protein commonly referred to as NPC1L1?: The complete designation for the protein commonly referred to as NPC1L1 is Niemann-Pick C1-Like 1.
  • What are the Entrez gene identification numbers for NPC1L1 in humans and mice?: The Entrez gene ID for human NPC1L1 is 29881, and for mouse NPC1L1, it is 237636.
  • What are the respective UniProt accession numbers for the NPC1L1 protein in humans and mice?: The UniProt accession number for human NPC1L1 is Q9UHC9, and for mouse NPC1L1, it is Q6T3U4.

Which of the following is NOT listed as an alternative name or symbol for NPC1L1?

Answer: CHOLABS1

Alternative names and symbols listed for NPC1L1 include NPC11L1, LDLCQ7, and SLC65A2. CHOLABS1 is not mentioned as such.

Related Concepts:

  • Beyond its primary designation, what other names or symbols are used to refer to NPC1L1?: Other names and symbols used for NPC1L1 include NPC11L1, NPC1 like intracellular cholesterol transporter 1, SLC65A2, and LDLCQ7.
  • What is the complete designation for the protein commonly referred to as NPC1L1?: The complete designation for the protein commonly referred to as NPC1L1 is Niemann-Pick C1-Like 1.
  • What are the Entrez gene identification numbers for NPC1L1 in humans and mice?: The Entrez gene ID for human NPC1L1 is 29881, and for mouse NPC1L1, it is 237636.

What is the UniProt accession number for the NPC1L1 protein in humans?

Answer: Q9UHC9

The UniProt accession number for human NPC1L1 is Q9UHC9.

Related Concepts:

  • What are the respective UniProt accession numbers for the NPC1L1 protein in humans and mice?: The UniProt accession number for human NPC1L1 is Q9UHC9, and for mouse NPC1L1, it is Q6T3U4.
  • What are the RefSeq protein accession numbers corresponding to the human NPC1L1 gene?: The RefSeq protein accession numbers for the human NPC1L1 gene are NP_001095118, NP_001287896, and NP_037521.
  • What are the Entrez gene identification numbers for NPC1L1 in humans and mice?: The Entrez gene ID for human NPC1L1 is 29881, and for mouse NPC1L1, it is 237636.

What is the Ensembl gene identifier for human NPC1L1?

Answer: ENSG00000015520

The Ensembl gene identifier for human NPC1L1 is ENSG00000015520.

Related Concepts:

  • Can you provide the Ensembl gene identifiers for NPC1L1 in both human and mouse genomes?: The Ensembl gene identifier for human NPC1L1 is ENSG00000015520, and for mouse NPC1L1, it is ENSMUSG00000020447.
  • What are the Entrez gene identification numbers for NPC1L1 in humans and mice?: The Entrez gene ID for human NPC1L1 is 29881, and for mouse NPC1L1, it is 237636.
  • What are the RefSeq protein accession numbers corresponding to the human NPC1L1 gene?: The RefSeq protein accession numbers for the human NPC1L1 gene are NP_001095118, NP_001287896, and NP_037521.

Which Entrez gene identification number corresponds to NPC1L1 in humans?

Answer: 29881

The Entrez gene identification number for human NPC1L1 is 29881.

Related Concepts:

  • What are the Entrez gene identification numbers for NPC1L1 in humans and mice?: The Entrez gene ID for human NPC1L1 is 29881, and for mouse NPC1L1, it is 237636.
  • Can you provide the Ensembl gene identifiers for NPC1L1 in both human and mouse genomes?: The Ensembl gene identifier for human NPC1L1 is ENSG00000015520, and for mouse NPC1L1, it is ENSMUSG00000020447.
  • What are the RefSeq protein accession numbers corresponding to the human NPC1L1 gene?: The RefSeq protein accession numbers for the human NPC1L1 gene are NP_001095118, NP_001287896, and NP_037521.

Which of the following is a RefSeq mRNA accession number for the human NPC1L1 gene?

Answer: NM_001300967

NM_001300967 is one of the RefSeq mRNA accession numbers listed for the human NPC1L1 gene.

Related Concepts:

  • What are the RefSeq protein accession numbers corresponding to the human NPC1L1 gene?: The RefSeq protein accession numbers for the human NPC1L1 gene are NP_001095118, NP_001287896, and NP_037521.
  • What are the various RefSeq mRNA accession numbers associated with the human NPC1L1 gene?: The human NPC1L1 gene is associated with the RefSeq mRNA accession numbers NM_001101648, NM_001300967, and NM_013389.
  • What are the respective UniProt accession numbers for the NPC1L1 protein in humans and mice?: The UniProt accession number for human NPC1L1 is Q9UHC9, and for mouse NPC1L1, it is Q6T3U4.

What does the source indicate regarding a RefSeq protein identifier for mouse NPC1L1?

Answer: It is listed as n/a (not available).

The provided text indicates that a RefSeq protein identifier for mouse NPC1L1 is not available (marked as n/a).

Related Concepts:

  • Does the provided text include a RefSeq protein identifier for the mouse NPC1L1?: No, the provided text indicates that there is no RefSeq protein identifier listed for mouse NPC1L1 (marked as n/a).
  • What are the respective UniProt accession numbers for the NPC1L1 protein in humans and mice?: The UniProt accession number for human NPC1L1 is Q9UHC9, and for mouse NPC1L1, it is Q6T3U4.
  • What are the RefSeq protein accession numbers corresponding to the human NPC1L1 gene?: The RefSeq protein accession numbers for the human NPC1L1 gene are NP_001095118, NP_001287896, and NP_037521.

Which database identifier is referenced for Protein Data Bank (PDB) structures related to NPC1L1?

Answer: 3QNT

The identifier 3QNT is specifically referenced in relation to Protein Data Bank (PDB) structures for NPC1L1.

Related Concepts:

  • Which external links provide access to structural information for NPC1L1?: The PDBe-KB database provides access to structural information for human NPC1L1 (UniProt Q9UHC9).
  • What are the respective UniProt accession numbers for the NPC1L1 protein in humans and mice?: The UniProt accession number for human NPC1L1 is Q9UHC9, and for mouse NPC1L1, it is Q6T3U4.
  • What are some of the key external databases that provide unique identifiers for the NPC1L1 gene or protein?: Key external databases that provide identifiers for NPC1L1 include OMIM (Online Mendelian Inheritance in Man), MGI (Mouse Genome Informatics), HomoloGene, GeneCards, and OMA (Orthologous Matrix).

Besides gene and protein databases, which resource hosts related media for NPC1L1?

Answer: Wikimedia Commons

Wikimedia Commons is cited as a resource that hosts media related to NPC1L1, in addition to standard biological databases.

Related Concepts:

  • Beyond standard gene and protein databases, what other external resources offer information or related media for NPC1L1?: External resources offering information on NPC1L1 include the U.S. National Library of Medicine's Medical Subject Headings (MeSH), the PDBe-KB database, Wikidata, and Wikimedia Commons, which hosts related media.
  • What are some of the key external databases that provide unique identifiers for the NPC1L1 gene or protein?: Key external databases that provide identifiers for NPC1L1 include OMIM (Online Mendelian Inheritance in Man), MGI (Mouse Genome Informatics), HomoloGene, GeneCards, and OMA (Orthologous Matrix).
  • Which external links provide access to structural information for NPC1L1?: The PDBe-KB database provides access to structural information for human NPC1L1 (UniProt Q9UHC9).

Which of the following is a key external database providing unique identifiers for NPC1L1 mentioned in the text?

Answer: Mouse Genome Informatics (MGI)

Mouse Genome Informatics (MGI) is listed as a key external database that provides unique identifiers for NPC1L1.

Related Concepts:

  • What are some of the key external databases that provide unique identifiers for the NPC1L1 gene or protein?: Key external databases that provide identifiers for NPC1L1 include OMIM (Online Mendelian Inheritance in Man), MGI (Mouse Genome Informatics), HomoloGene, GeneCards, and OMA (Orthologous Matrix).
  • Beyond standard gene and protein databases, what other external resources offer information or related media for NPC1L1?: External resources offering information on NPC1L1 include the U.S. National Library of Medicine's Medical Subject Headings (MeSH), the PDBe-KB database, Wikidata, and Wikimedia Commons, which hosts related media.
  • What are the RefSeq protein accession numbers corresponding to the human NPC1L1 gene?: The RefSeq protein accession numbers for the human NPC1L1 gene are NP_001095118, NP_001287896, and NP_037521.

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