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The New England Journal of Medicine: History, Publications, and Impact

At a Glance

Title: The New England Journal of Medicine: History, Publications, and Impact

Total Categories: 7

Category Stats

  • Genesis and Historical Trajectory: 9 flashcards, 8 questions
  • Publisher and Editorial Leadership: 2 flashcards, 3 questions
  • Publication Practices and Policies: 8 flashcards, 6 questions
  • Journal Scope and Identification: 7 flashcards, 9 questions
  • Seminal Research and Medical Milestones: 12 flashcards, 14 questions
  • Digital Evolution and Contemporary Initiatives: 7 flashcards, 6 questions
  • Recognition, Impact, and Critiques: 4 flashcards, 1 questions

Total Stats

  • Total Flashcards: 54
  • True/False Questions: 29
  • Multiple Choice Questions: 25
  • Total Questions: 54

Instructions

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Welcome to Your Curriculum Command Center

This guide will turn you into a Wiki2web Studio power user. Let's unlock the features designed to give you back your weekends.

The Core Concept: What is a "Kit"?

Think of a Kit as your all-in-one digital lesson plan. It's a single, portable file that contains every piece of content for a topic: your subject categories, a central image, all your flashcards, and all your questions. The true power of the Studio is speed—once a kit is made (or you import one), you are just minutes away from printing an entire set of coursework.

Getting Started is Simple:

  • Create New Kit: Start with a clean slate. Perfect for a brand-new lesson idea.
  • Import & Edit Existing Kit: Load a .json kit file from your computer to continue your work or to modify a kit created by a colleague.
  • Restore Session: The Studio automatically saves your progress in your browser. If you get interrupted, you can restore your unsaved work with one click.

Step 1: Laying the Foundation (The Authoring Tools)

This is where you build the core knowledge of your Kit. Use the left-side navigation panel to switch between these powerful authoring modules.

⚙️ Kit Manager: Your Kit's Identity

This is the high-level control panel for your project.

  • Kit Name: Give your Kit a clear title. This will appear on all your printed materials.
  • Master Image: Upload a custom cover image for your Kit. This is essential for giving your content a professional visual identity, and it's used as the main graphic when you export your Kit as an interactive game.
  • Topics: Create the structure for your lesson. Add topics like "Chapter 1," "Vocabulary," or "Key Formulas." All flashcards and questions will be organized under these topics.

🃏 Flashcard Author: Building the Knowledge Blocks

Flashcards are the fundamental concepts of your Kit. Create them here to define terms, list facts, or pose simple questions.

  • Click "➕ Add New Flashcard" to open the editor.
  • Fill in the term/question and the definition/answer.
  • Assign the flashcard to one of your pre-defined topics.
  • To edit or remove a flashcard, simply use the ✏️ (Edit) or ❌ (Delete) icons next to any entry in the list.

✍️ Question Author: Assessing Understanding

Create a bank of questions to test knowledge. These questions are the engine for your worksheets and exams.

  • Click "➕ Add New Question".
  • Choose a Type: True/False for quick checks or Multiple Choice for more complex assessments.
  • To edit an existing question, click the ✏️ icon. You can change the question text, options, correct answer, and explanation at any time.
  • The Explanation field is a powerful tool: the text you enter here will automatically appear on the teacher's answer key and on the Smart Study Guide, providing instant feedback.

🔗 Intelligent Mapper: The Smart Connection

This is the secret sauce of the Studio. The Mapper transforms your content from a simple list into an interconnected web of knowledge, automating the creation of amazing study guides.

  • Step 1: Select a question from the list on the left.
  • Step 2: In the right panel, click on every flashcard that contains a concept required to answer that question. They will turn green, indicating a successful link.
  • The Payoff: When you generate a Smart Study Guide, these linked flashcards will automatically appear under each question as "Related Concepts."

Step 2: The Magic (The Generator Suite)

You've built your content. Now, with a few clicks, turn it into a full suite of professional, ready-to-use materials. What used to take hours of formatting and copying-and-pasting can now be done in seconds.

🎓 Smart Study Guide Maker

Instantly create the ultimate review document. It combines your questions, the correct answers, your detailed explanations, and all the "Related Concepts" you linked in the Mapper into one cohesive, printable guide.

📝 Worksheet & 📄 Exam Builder

Generate unique assessments every time. The questions and multiple-choice options are randomized automatically. Simply select your topics, choose how many questions you need, and generate:

  • A Student Version, clean and ready for quizzing.
  • A Teacher Version, complete with a detailed answer key and the explanations you wrote.

🖨️ Flashcard Printer

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Step 3: Saving and Collaborating

  • 💾 Export & Save Kit: This is your primary save function. It downloads the entire Kit (content, images, and all) to your computer as a single .json file. Use this to create permanent backups and share your work with others.
  • ➕ Import & Merge Kit: Combine your work. You can merge a colleague's Kit into your own or combine two of your lessons into a larger review Kit.

You're now ready to reclaim your time.

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Study Guide: The New England Journal of Medicine: History, Publications, and Impact

Study Guide: The New England Journal of Medicine: History, Publications, and Impact

Genesis and Historical Trajectory

The NEJM was founded in the 19th century by a physician named John Collins Warren.

Answer: True

The founding of The New England Journal of Medicine occurred in 1812, which is in the 19th century, by John Collins Warren.

Related Concepts:

  • When was The New England Journal of Medicine founded, and by whom?: The New England Journal of Medicine was founded in 1812 by Boston physician John Collins Warren, along with James Jackson, who submitted a prospectus to establish it as a medical and philosophical journal.
  • What does the date '1812' signify in the context of NEJM's history?: The year 1812 signifies the founding of the journal's earliest predecessor, the 'New England Journal of Medicine and Surgery and Collateral Branches of Science'.

Initially, upon its founding in 1812, the journal was published on a quarterly basis.

Answer: True

The journal's initial publication frequency upon its founding in 1812 was quarterly.

Related Concepts:

  • What was the initial publication frequency of the journal?: Upon its founding in January 1812, the journal, then named the New England Journal of Medicine and Surgery and the Collateral Branches of Medical Science, was published quarterly.
  • What does the date '1812' signify in the context of NEJM's history?: The year 1812 signifies the founding of the journal's earliest predecessor, the 'New England Journal of Medicine and Surgery and Collateral Branches of Science'.

The journal adopted its current name, The New England Journal of Medicine, in 1928.

Answer: True

The journal was officially renamed The New England Journal of Medicine in 1928.

Related Concepts:

  • What does the date '1928' signify in the context of NEJM's history?: The year 1928 signifies the official renaming of the journal to 'The New England Journal of Medicine'.
  • How did the journal evolve through mergers and name changes?: The journal evolved through several stages: it began as the New England Journal of Medicine and Surgery, merged with the Boston Medical Intelligencer in 1828 to become the Boston Medical and Surgical Journal (shifting to weekly publication), and was finally renamed The New England Journal of Medicine in 1928 after being purchased by the Massachusetts Medical Society.

The Massachusetts Medical Society purchased the journal in 1921 for US$1.

Answer: True

The Massachusetts Medical Society acquired the journal in 1921 for US$1, with the journal being renamed The New England Journal of Medicine in 1928.

Related Concepts:

  • What is the historical significance of the Massachusetts Medical Society's purchase of the journal?: The Massachusetts Medical Society purchased the journal in 1921 for US$1, ensuring its continued publication and eventual renaming to The New England Journal of Medicine in 1928, solidifying its institutional backing.
  • What does the date '1928' signify in the context of NEJM's history?: The year 1928 signifies the official renaming of the journal to 'The New England Journal of Medicine'.

Who is credited as the founder of The New England Journal of Medicine in 1812?

Answer: John Collins Warren

John Collins Warren is credited as the founder of the journal in 1812.

Related Concepts:

  • When was The New England Journal of Medicine founded, and by whom?: The New England Journal of Medicine was founded in 1812 by Boston physician John Collins Warren, along with James Jackson, who submitted a prospectus to establish it as a medical and philosophical journal.
  • What does the date '1812' signify in the context of NEJM's history?: The year 1812 signifies the founding of the journal's earliest predecessor, the 'New England Journal of Medicine and Surgery and Collateral Branches of Science'.

In 1828, the journal merged with the 'Boston Medical Intelligencer', leading to the formation of the 'Boston Medical and Surgical Journal' and a shift to weekly publication.

Answer: True

The merger in 1828 involved the 'Boston Medical Intelligencer' and resulted in the 'Boston Medical and Surgical Journal', which adopted a weekly publication schedule.

Related Concepts:

  • What is the historical context of the 'Boston Medical Intelligencer' in relation to NEJM?: The 'Boston Medical Intelligencer' was a weekly publication that merged with the 'New England Journal of Medicine and Surgery' in 1828 to form the 'Boston Medical and Surgical Journal', a key step in the lineage of the current NEJM.
  • What is the historical significance of the name 'Boston Medical and Surgical Journal'?: The 'Boston Medical and Surgical Journal' was the name adopted in 1828 after the merger of two earlier publications, marking a shift to weekly publication and serving as a predecessor to the current NEJM.

What does the date '1828' signify in the history of NEJM's predecessors?

Answer: The merger with the Boston Medical Intelligencer and shift to weekly publication.

The year 1828 signifies the merger with the 'Boston Medical Intelligencer', leading to the formation of the 'Boston Medical and Surgical Journal' and a shift to weekly publication.

Related Concepts:

  • What does the date '1928' signify in the context of NEJM's history?: The year 1928 signifies the official renaming of the journal to 'The New England Journal of Medicine'.
  • What is the historical significance of the name 'Boston Medical and Surgical Journal'?: The 'Boston Medical and Surgical Journal' was the name adopted in 1828 after the merger of two earlier publications, marking a shift to weekly publication and serving as a predecessor to the current NEJM.
  • What is the historical context of the 'Boston Medical Intelligencer' in relation to NEJM?: The 'Boston Medical Intelligencer' was a weekly publication that merged with the 'New England Journal of Medicine and Surgery' in 1828 to form the 'Boston Medical and Surgical Journal', a key step in the lineage of the current NEJM.

What historical event does the date '1928' represent in the NEJM's history?

Answer: The official renaming of the journal to The New England Journal of Medicine.

The year 1928 signifies the official renaming of the journal to 'The New England Journal of Medicine'.

Related Concepts:

  • What does the date '1928' signify in the context of NEJM's history?: The year 1928 signifies the official renaming of the journal to 'The New England Journal of Medicine'.
  • What was the first article published in the journal's current format in 1928?: The article 'The Journal's New Look' published in February 1928 marked the first use of the present name, The New England Journal of Medicine, and discussed the journal's evolving presentation.
  • How did the journal evolve through mergers and name changes?: The journal evolved through several stages: it began as the New England Journal of Medicine and Surgery, merged with the Boston Medical Intelligencer in 1828 to become the Boston Medical and Surgical Journal (shifting to weekly publication), and was finally renamed The New England Journal of Medicine in 1928 after being purchased by the Massachusetts Medical Society.

Publisher and Editorial Leadership

The New England Journal of Medicine (NEJM) is published weekly by the Massachusetts Medical Society.

Answer: True

The source material indicates that NEJM is published weekly by the Massachusetts Medical Society.

Related Concepts:

  • What is The New England Journal of Medicine (NEJM)?: The New England Journal of Medicine (NEJM) is a weekly peer-reviewed medical journal published by the Massachusetts Medical Society. It is recognized as one of the most prestigious and influential medical journals globally.
  • Who is the publisher of The New England Journal of Medicine?: The New England Journal of Medicine is published by the Massachusetts Medical Society in the United States.

Eric Rubin is the current editor-in-chief of The New England Journal of Medicine.

Answer: True

Eric Rubin holds the position of current editor-in-chief for The New England Journal of Medicine.

Related Concepts:

  • Who is the current editor-in-chief of The New England Journal of Medicine?: The current editor-in-chief of The New England Journal of Medicine is Eric Rubin.

The Massachusetts Medical Society is the publisher of The New England Journal of Medicine.

Answer: True

The Massachusetts Medical Society serves as the publisher for The New England Journal of Medicine.

Related Concepts:

  • Who is the publisher of The New England Journal of Medicine?: The New England Journal of Medicine is published by the Massachusetts Medical Society in the United States.

Publication Practices and Policies

NEJM articles become open access immediately upon publication.

Answer: False

NEJM articles are typically made available through delayed open access six months after publication, although articles of global public health importance may be immediately accessible.

Related Concepts:

  • What is the open access policy for NEJM articles?: NEJM offers delayed open access, making articles freely available six months after publication. Additionally, articles of global and public health importance are made freely available immediately upon publication on NEJM.org.
  • What does the 'delayed (6 months)' open access status imply for readers of NEJM?: It implies that while the latest research articles are initially behind a paywall or subscription, they become freely accessible to all readers on NEJM.org six months after their publication date.

Authors are charged significant fees for submitting and publishing articles in NEJM.

Answer: False

The New England Journal of Medicine does not charge authors any submission or publication fees.

Related Concepts:

  • Does NEJM charge authors for article submission or publication?: No, NEJM does not charge authors any submission or publication fees.

The Ingelfinger rule requires that submitted articles must not have been previously published or released elsewhere.

Answer: True

The Ingelfinger rule mandates that articles submitted to NEJM must not have been previously published or released elsewhere, ensuring peer review precedes dissemination.

Related Concepts:

  • What is the Ingelfinger rule, and what is its purpose?: The Ingelfinger rule is a policy maintained by NEJM that requires articles submitted for publication not to have been previously published or released elsewhere. Its purpose is to ensure that research undergoes peer review before being widely disseminated to the public or profession.
  • What is the stated goal of the Ingelfinger rule regarding research dissemination?: The Ingelfinger rule aims to protect the newsworthiness of research by ensuring it undergoes peer review by the journal before being promoted to the public or the medical profession.

According to NEJM's open access policy, when are articles typically made freely available?

Answer: Six months after publication

NEJM articles are typically made freely available six months after their initial publication date.

Related Concepts:

  • What is the open access policy for NEJM articles?: NEJM offers delayed open access, making articles freely available six months after publication. Additionally, articles of global and public health importance are made freely available immediately upon publication on NEJM.org.
  • What does the 'delayed (6 months)' open access status imply for readers of NEJM?: It implies that while the latest research articles are initially behind a paywall or subscription, they become freely accessible to all readers on NEJM.org six months after their publication date.

The Ingelfinger rule, maintained by NEJM, primarily serves to:

Answer: Ensure all published articles are peer-reviewed before public release.

The Ingelfinger rule mandates that research submitted to NEJM must not have been previously published or released elsewhere. Its primary purpose is to ensure that all published research has undergone rigorous peer review before dissemination to the professional community and the public.

Related Concepts:

  • What is the Ingelfinger rule, and what is its purpose?: The Ingelfinger rule is a policy maintained by NEJM that requires articles submitted for publication not to have been previously published or released elsewhere. Its purpose is to ensure that research undergoes peer review before being widely disseminated to the public or profession.
  • What is the stated goal of the Ingelfinger rule regarding research dissemination?: The Ingelfinger rule aims to protect the newsworthiness of research by ensuring it undergoes peer review by the journal before being promoted to the public or the medical profession.
  • Who first articulated the Ingelfinger rule?: The Ingelfinger rule was first described in a 1969 editorial titled 'Definition of Sole Contribution' by Franz Ingelfinger, who was the editor-in-chief of NEJM at that time.

What policy does NEJM maintain regarding the prior release of submitted research?

Answer: Articles must not have been previously published or released elsewhere.

NEJM maintains a policy that articles submitted for publication must not have been previously published or released elsewhere.

Related Concepts:

  • What is the Ingelfinger rule, and what is its purpose?: The Ingelfinger rule is a policy maintained by NEJM that requires articles submitted for publication not to have been previously published or released elsewhere. Its purpose is to ensure that research undergoes peer review before being widely disseminated to the public or profession.

Journal Scope and Identification

The primary focus of The New England Journal of Medicine is engineering and technology.

Answer: False

The primary discipline covered by The New England Journal of Medicine is Medicine, not engineering and technology.

Related Concepts:

  • What is the primary discipline covered by The New England Journal of Medicine?: The primary discipline covered by The New England Journal of Medicine is Medicine.

The New England Journal of Medicine is published in multiple languages, including French and Spanish.

Answer: False

The New England Journal of Medicine is published exclusively in English.

Related Concepts:

  • In what language is The New England Journal of Medicine published?: The New England Journal of Medicine is published in English.

The NEJM logo features the Rod of Asclepius symbol crossed with a quill pen.

Answer: True

The NEJM logo depicts the Rod of Asclepius crossed over a quill pen.

Related Concepts:

  • What does the NEJM logo symbolize?: The NEJM logo depicts the Rod of Asclepius crossed over a quill pen. The dates incorporated into the logo represent the founding years of its predecessor publications: 1812, 1823, 1828, and 1928.

The CODEN identifier for The New England Journal of Medicine is NEJMAG.

Answer: True

The CODEN identifier assigned to The New England Journal of Medicine is NEJMAG.

Related Concepts:

  • What is the CODEN identifier for The New England Journal of Medicine?: The CODEN identifier for The New England Journal of Medicine is NEJMAG.
  • What is the primary discipline covered by The New England Journal of Medicine?: The primary discipline covered by The New England Journal of Medicine is Medicine.

What is the primary role of The New England Journal of Medicine (NEJM)?

Answer: A prestigious, globally recognized weekly peer-reviewed medical journal.

The New England Journal of Medicine functions as a prestigious, globally recognized weekly peer-reviewed medical journal.

Related Concepts:

  • What is The New England Journal of Medicine (NEJM)?: The New England Journal of Medicine (NEJM) is a weekly peer-reviewed medical journal published by the Massachusetts Medical Society. It is recognized as one of the most prestigious and influential medical journals globally.
  • What is the primary discipline covered by The New England Journal of Medicine?: The primary discipline covered by The New England Journal of Medicine is Medicine.

What is the current publication frequency of The New England Journal of Medicine?

Answer: Weekly

The New England Journal of Medicine is currently published on a weekly basis.

Related Concepts:

  • What is the publication frequency of The New England Journal of Medicine?: The New England Journal of Medicine is published weekly.
  • What is The New England Journal of Medicine (NEJM)?: The New England Journal of Medicine (NEJM) is a weekly peer-reviewed medical journal published by the Massachusetts Medical Society. It is recognized as one of the most prestigious and influential medical journals globally.

What does the NEJM logo symbolize, combining medical and literary elements?

Answer: The Rod of Asclepius crossed over a quill pen

The NEJM logo symbolizes the Rod of Asclepius crossed over a quill pen, representing medicine and scholarly writing.

Related Concepts:

  • What does the NEJM logo symbolize?: The NEJM logo depicts the Rod of Asclepius crossed over a quill pen. The dates incorporated into the logo represent the founding years of its predecessor publications: 1812, 1823, 1828, and 1928.

What is the CODEN identifier assigned to The New England Journal of Medicine?

Answer: NEJMAG

The CODEN identifier assigned to The New England Journal of Medicine is NEJMAG.

Related Concepts:

  • What is the CODEN identifier for The New England Journal of Medicine?: The CODEN identifier for The New England Journal of Medicine is NEJMAG.
  • What are the print and online ISSNs for The New England Journal of Medicine?: The print ISSN for The New England Journal of Medicine is 0028-4793, and the web ISSN is 1533-4406.
  • What is the primary discipline covered by The New England Journal of Medicine?: The primary discipline covered by The New England Journal of Medicine is Medicine.

What does the print ISSN for The New England Journal of Medicine indicate?

Answer: A standard number assigned to the print version for identification.

The print ISSN (International Standard Serial Number) for The New England Journal of Medicine is 0028-4793, serving as a standard numerical identifier for the print edition.

Related Concepts:

  • What are the print and online ISSNs for The New England Journal of Medicine?: The print ISSN for The New England Journal of Medicine is 0028-4793, and the web ISSN is 1533-4406.
  • What is the CODEN identifier for The New England Journal of Medicine?: The CODEN identifier for The New England Journal of Medicine is NEJMAG.

Seminal Research and Medical Milestones

Henry Jacob Bigelow's 1846 report in NEJM detailed the first successful use of ether as a general anesthetic.

Answer: True

In November 1846, the journal published Henry Jacob Bigelow's report on the first public demonstration of inhaled ether as a generalized anesthetic.

Related Concepts:

  • What significant medical report was published in NEJM in November 1846?: In November 1846, the journal published Henry Jacob Bigelow's report on the first public demonstration of inhaled ether as a generalized anesthetic, which revolutionized surgical procedures by rendering patients insensible to pain.
  • What role did the NEJM play in the early reporting of anesthesia?: In November 1846, NEJM published Henry Jacob Bigelow's report on the first public demonstration of inhaled ether as a generalized anesthetic, documenting this major advancement in medical practice.

James Homer Wright's 1906 article detailed observations of megakaryocytes and platelets.

Answer: True

James Homer Wright's 1906 publication in NEJM described observations of megakaryocytes and platelets.

Related Concepts:

  • What discovery concerning blood components was detailed in a 1906 article by James Homer Wright?: In June 1906, James Homer Wright published an article describing his study of bone marrow, which included detailed observations of what are now known as megakaryocytes and platelets.

Charles-Édouard Brown-Séquard's 1872 publication proposed that one cerebral hemisphere could influence both sides of the body.

Answer: True

Brown-Séquard's 1872 publication suggested that one cerebral hemisphere could influence both sides of the body, and he is also known for describing the Brown-Séquard syndrome.

Related Concepts:

  • What revolutionary neurological concept was presented in a lecture published in NEJM in October 1872?: In October 1872, a lecture by Charles-Édouard Brown-Séquard was published, proposing the concept that one cerebral hemisphere could influence both sides of the body, and he later described what is now known as the Brown-Séquard syndrome.

Sidney Farber reported success in treating childhood leukemia using aminopterin in 1948.

Answer: True

In June 1948, Sidney Farber reported promising results in treating acute lymphoblastic leukemia in children using aminopterin.

Related Concepts:

  • What breakthrough in treating childhood leukemia was reported by Sidney Farber in 1948?: In June 1948, Sidney Farber reported promising results in treating acute lymphoblastic leukemia in children using aminopterin, a folic acid inhibitor, leading to temporary remissions.

Paul Zoll's 1952 publication detailed the use of an external electric pacemaker for ventricular standstill.

Answer: True

Paul Zoll's 1952 report described the use of an external electric pacemaker to treat ventricular standstill.

Related Concepts:

  • What innovation in cardiac resuscitation was published by Paul Zoll in 1952?: In November 1952, cardiologist Paul Zoll published a report on the successful use of an external electric pacemaker to revive the heart from ventricular standstill, a significant advancement for patients experiencing cardiac arrest.

A 1973 article in NEJM introduced the concept of polyp removal via colonoscopy for cancer prevention.

Answer: True

In February 1973, the journal published the first report on polyp removal using a colonoscope, a procedure that could reduce cancer risk.

Related Concepts:

  • What new endoscopic procedure for cancer risk reduction was introduced in a 1973 NEJM article?: In February 1973, the journal published the first report on polyp removal using a colonoscope, introducing a procedure that could reduce cancer risk by removing polyps during endoscopic screening.

Landmark articles describing the disease now known as AIDS were published in NEJM in December 1981.

Answer: True

In December 1981, two landmark articles published in NEJM described the clinical course of patients with the disease that would become known as AIDS.

Related Concepts:

  • What significant disease was described in landmark articles in NEJM in December 1981?: In December 1981, two landmark articles published in NEJM described the clinical course of four patients with the disease that would eventually be known as AIDS (Acquired Immunodeficiency Syndrome).

Brian Druker's 2001 NEJM report focused on a new treatment for chronic myelogenous leukemia (CML).

Answer: True

Brian Druker's 2001 report detailed a targeted therapy for chronic myelogenous leukemia (CML).

Related Concepts:

  • What targeted therapy for chronic myelogenous leukemia was reported in NEJM in April 2001?: In April 2001, Brian Druker and colleagues reported on the efficacy of a specific inhibitor of the BCR-ABL tyrosine kinase for treating chronic myelogenous leukemia, initiating an era of targeted cancer therapies.
  • What specific type of therapy for chronic myelogenous leukemia was reported in the 2001 NEJM article?: The 2001 NEJM article reported on a targeted therapy using an inhibitor of the BCR-ABL tyrosine kinase, which specifically targets the molecular abnormality causing chronic myelogenous leukemia.

A 2021 study compared psilocybin to an SSRI for treating major depressive disorder, finding no significant difference in effectiveness after six weeks.

Answer: True

The 2021 NEJM study comparing psilocybin and escitalopram for major depressive disorder found no significant difference in effectiveness between the two treatments after six weeks.

Related Concepts:

  • What comparison between psilocybin and an SSRI for depression treatment was published in April 2021?: In April 2021, NEJM published a study by Robin Carhart-Harris et al. that compared the psychedelic drug psilocybin with the SSRI escitalopram for treating major depressive disorder, finding no significant difference in antidepressant effects after six weeks.
  • What is the significance of the 2021 NEJM study comparing psilocybin and escitalopram?: This study was significant as it was the first time a psychedelic drug (psilocybin) and a leading SSRI antidepressant (escitalopram) were directly compared in the treatment of depression, showing comparable effectiveness.

Which significant medical advancement was reported in NEJM in November 1846?

Answer: The first public demonstration of ether as a general anesthetic

The report on the first public demonstration of ether as a general anesthetic was published in NEJM in November 1846.

Related Concepts:

  • What significant medical report was published in NEJM in November 1846?: In November 1846, the journal published Henry Jacob Bigelow's report on the first public demonstration of inhaled ether as a generalized anesthetic, which revolutionized surgical procedures by rendering patients insensible to pain.
  • What role did the NEJM play in the early reporting of anesthesia?: In November 1846, NEJM published Henry Jacob Bigelow's report on the first public demonstration of inhaled ether as a generalized anesthetic, documenting this major advancement in medical practice.

What discovery related to blood components was detailed by James Homer Wright in 1906?

Answer: The description of megakaryocytes and platelets

James Homer Wright's 1906 article detailed observations of megakaryocytes and platelets.

Related Concepts:

  • What discovery concerning blood components was detailed in a 1906 article by James Homer Wright?: In June 1906, James Homer Wright published an article describing his study of bone marrow, which included detailed observations of what are now known as megakaryocytes and platelets.

In December 1981, NEJM published landmark articles describing the initial cases of which disease?

Answer: Acquired Immunodeficiency Syndrome (AIDS)

In December 1981, NEJM published landmark articles describing the initial cases of what would become known as Acquired Immunodeficiency Syndrome (AIDS).

Related Concepts:

  • What significant disease was described in landmark articles in NEJM in December 1981?: In December 1981, two landmark articles published in NEJM described the clinical course of four patients with the disease that would eventually be known as AIDS (Acquired Immunodeficiency Syndrome).

What type of therapy for chronic myelogenous leukemia (CML) was reported by Brian Druker and colleagues in NEJM in 2001?

Answer: A targeted inhibitor of the BCR-ABL tyrosine kinase

The 2001 NEJM report by Brian Druker and colleagues detailed a targeted therapy using an inhibitor of the BCR-ABL tyrosine kinase for chronic myelogenous leukemia (CML).

Related Concepts:

  • What targeted therapy for chronic myelogenous leukemia was reported in NEJM in April 2001?: In April 2001, Brian Druker and colleagues reported on the efficacy of a specific inhibitor of the BCR-ABL tyrosine kinase for treating chronic myelogenous leukemia, initiating an era of targeted cancer therapies.
  • What specific type of therapy for chronic myelogenous leukemia was reported in the 2001 NEJM article?: The 2001 NEJM article reported on a targeted therapy using an inhibitor of the BCR-ABL tyrosine kinase, which specifically targets the molecular abnormality causing chronic myelogenous leukemia.

The 2021 study comparing psilocybin and escitalopram for depression found:

Answer: There was no significant difference in effectiveness between the two treatments after six weeks.

The 2021 NEJM study comparing psilocybin and escitalopram for major depressive disorder found no significant difference in effectiveness between the two treatments after six weeks.

Related Concepts:

  • What comparison between psilocybin and an SSRI for depression treatment was published in April 2021?: In April 2021, NEJM published a study by Robin Carhart-Harris et al. that compared the psychedelic drug psilocybin with the SSRI escitalopram for treating major depressive disorder, finding no significant difference in antidepressant effects after six weeks.
  • What is the significance of the 2021 NEJM study comparing psilocybin and escitalopram?: This study was significant as it was the first time a psychedelic drug (psilocybin) and a leading SSRI antidepressant (escitalopram) were directly compared in the treatment of depression, showing comparable effectiveness.

Digital Evolution and Contemporary Initiatives

NEJM launched its website and began electronic publication in 1996.

Answer: True

NEJM launched its website and commenced electronic publication on April 25, 1996.

Related Concepts:

  • When did NEJM first launch its website and begin electronic publication?: NEJM announced its new website and began electronic publication on April 25, 1996, initially publishing abstracts of research articles and the full text of editorials, cases, and letters.

NEJM Evidence is a monthly publication focused on original research and clinical trials in medicine.

Answer: True

NEJM Evidence, launched in 2022, is a monthly digital sub-journal dedicated to publishing original research and clinical trials in medicine.

Related Concepts:

  • What is NEJM Evidence, and when was it established?: NEJM Evidence is a monthly digital sub-journal launched in 2022 by NEJM, dedicated to publishing original research, clinical trials, and decision-making in medicine.
  • What is the frequency of publication for the specialty journal NEJM Evidence?: NEJM Evidence, a specialty journal established by NEJM, is published monthly.

NEJM launched its website and began electronic publication on which date?

Answer: April 25, 1996

NEJM launched its website and commenced electronic publication on April 25, 1996.

Related Concepts:

  • When did NEJM first launch its website and begin electronic publication?: NEJM announced its new website and began electronic publication on April 25, 1996, initially publishing abstracts of research articles and the full text of editorials, cases, and letters.

Which of the following is NOT a feature developed by NEJM to enhance its digital presence?

Answer: A comprehensive medical coding simulator

While NEJM offers features like 'Videos in Clinical Medicine,' 'Interactive Medical Cases,' and the 'NEJM Archive' to enhance its digital presence, a comprehensive medical coding simulator is not among the listed digital features.

Related Concepts:

  • What online features has NEJM developed to enhance its digital presence?: NEJM has developed features such as 'Videos in Clinical Medicine' for teaching procedures, 'Interactive Medical Cases' for simulating clinical encounters, and the 'NEJM Archive' for accessing its entire collection of published material.
  • When did NEJM first launch its website and begin electronic publication?: NEJM announced its new website and began electronic publication on April 25, 1996, initially publishing abstracts of research articles and the full text of editorials, cases, and letters.
  • What types of content are available on the NEJM website beyond research articles?: The NEJM website offers full-text access to editorials, cases, and letters to the editor, as well as features like 'Videos in Clinical Medicine,' 'Interactive Medical Cases,' and the 'NEJM Archive'.

What is the primary focus of the NEJM sub-journal 'NEJM Evidence,' launched in 2022?

Answer: Publishing original research and clinical trials in medicine

NEJM Evidence is dedicated to publishing original research and clinical trials in medicine.

Related Concepts:

  • What is NEJM Evidence, and when was it established?: NEJM Evidence is a monthly digital sub-journal launched in 2022 by NEJM, dedicated to publishing original research, clinical trials, and decision-making in medicine.
  • What is the frequency of publication for the specialty journal NEJM Evidence?: NEJM Evidence, a specialty journal established by NEJM, is published monthly.

The 'Videos in Clinical Medicine' feature on the NEJM website is primarily intended to:

Answer: Teach medical procedures and examination techniques

The 'Videos in Clinical Medicine' feature is designed to teach skilled techniques and specialized physical examinations required in medical practice.

Related Concepts:

  • What online features has NEJM developed to enhance its digital presence?: NEJM has developed features such as 'Videos in Clinical Medicine' for teaching procedures, 'Interactive Medical Cases' for simulating clinical encounters, and the 'NEJM Archive' for accessing its entire collection of published material.
  • What is the purpose of the 'Videos in Clinical Medicine' feature?: The 'Videos in Clinical Medicine' feature provides peer-reviewed educational videos designed to teach skilled techniques and specialized physical examinations required in medical practice.

Recognition, Impact, and Critiques

What was the significance of the 1977 George Polk Award given to NEJM?

Answer: It marked the journal's first major award.

The 1977 George Polk Award was significant as it provided The New England Journal of Medicine with its first substantial mainstream visibility, contributing to its subsequent prestige and recognition.

Related Concepts:

  • What recognition did NEJM receive from the George Polk Awards?: The George Polk Awards recognized NEJM in 1977, stating that the award provided the journal with its first significant mainstream visibility, paving the way for its subsequent prestige and attention.
  • How has NEJM's influence in the medical field been recognized?: NEJM's influence is recognized through awards like the George Polk Award in 1977 and its consistently high impact factor, often ranking first among general and internal medicine journals, demonstrating its significant prestige and reach.

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