What is the full name and abbreviation of the research institute located in Hyderabad, India, and what is its primary field of research?

The research institute located in Hyderabad, India, is the Centre for Cellular and Molecular Biology, commonly abbreviated as CCMB. It is an Indian fundamental life science research establishment.

Under which government body does the Centre for Cellular and Molecular Biology (CCMB) operate?

The Centre for Cellular and Molecular Biology (CCMB) operates under the aegis of the Council of Scientific and Industrial Research (CSIR), which is an autonomous government body.

What international recognition has CCMB received from UNESCO?

CCMB has been designated as a "Centre of Excellence" by the Global Molecular and Cell Biology Network, which is associated with UNESCO.

When was the Centre for Cellular and Molecular Biology established, and who was its first director?

The Centre for Cellular and Molecular Biology (CCMB) was established on April 1, 1977. Its first director was Dr. P. M. Bhargava.

What was the initial setup for CCMB, and when did it achieve the status of a full-fledged national laboratory?

CCMB was initially set up as a semi-autonomous Centre, with the Biochemistry Division of the Regional Research Laboratory (now IICT) forming its nucleus. It was accorded the status of a full-fledged national laboratory with its own Executive Committee and Scientific Advisory Council during 1981-82.

What are the three major categories of research programs conducted at CCMB?

The three major categories of research programs at CCMB are: 1) high-quality basic research in frontier areas of modern biology, 2) research relevant to societal needs, and 3) application-oriented research towards commercialization.

Can you list at least five specific research areas within modern biology that CCMB investigates?

CCMB investigates several specific research areas, including evolution & development, gene regulation in prokaryotes and eukaryotes, host-parasite interactions, membrane biology, protein structure, stem cell biology, neurobiology, bioinformatics, functional genomics, and ecology and ecosystems.

How does LaCONES contribute to wildlife conservation efforts in India, particularly concerning wildlife crime and endangered species?

LaCONES assists the Government of India by identifying the source of animal meat in cases of doubt, tracing sources of smuggled animals, studying stress among wild animals non-invasively, and helping identify reasons for bird hits near airports. They have also worked on projects like protecting the mouse deer from extinction and facilitating their release into natural habitats.

What is the role of the Atal Incubation Centre-CCMB (AIC-CCMB) within the Innovation Hub?

The Atal Incubation Centre-CCMB (AIC-CCMB) functions within the Innovation Hub to support early-stage life science startups. This initiative is backed by NITI Aayog and the Atal Innovation Mission.

How does CCMB support startups in the life sciences sector through AIC-CCMB and the Meity Startup Hub?

CCMB supports startups working in areas such as drug discovery, drug repurposing, vaccine development, diagnostics, nutrition, and nanomaterial development through AIC-CCMB. Additionally, it hosts a Meity Startup Hub to incubate startups focused on big data in the life sciences and healthcare sectors.

What is the admission process for CCMB's PhD program?

To join CCMB's PhD program, prospective students must apply for their application test, which is followed by interviews. The program typically has two rounds of intake each year.

What are the typical sources of fellowships for students pursuing a PhD at CCMB?

Most students joining CCMB's PhD program secure their own fellowships from organizations such as CSIR, UGC, DBT, ICMR, or DST.

What career paths do CCMB PhD program alumni typically pursue?

Alumni from CCMB's PhD program predominantly continue their careers in academia or join the life science industry, both within India and internationally. They are often found in premier research and educational institutes across India.

Can you name at least three national research institutes with which CCMB actively collaborates?

CCMB actively collaborates with several national research institutes, including the Tata Institute of Fundamental Research (TIFR), inStem, ICAR-Indian Institute of Rice Research, University of Hyderabad, and CSIR-Institute of Genomics and Integrative Biology (IGIB).

Name at least three international institutions that provide funding for CCMB's collaborative projects.

CCMB receives funding for collaborative projects from international institutions such as the National Institutes of Health (NIH), Harvard Medical School, and Massachusetts Institute of Technology in the United States; the Imperial Cancer Research Fund and Cambridge University in the United Kingdom; and the Centre Nationale de la Recherche Scientifique (CNRS) and Pasteur Institute in France.

What specific translational research is CCMB undertaking in collaboration with the University of Nebraska Medical Center?

CCMB is collaborating with the University of Nebraska Medical Center on translational research specifically focused on glaucoma.

What significant technological achievement did CCMB develop in India related to DNA analysis, and what was its global standing?

CCMB developed the DNA Fingerprinting Technology in India, making India the third country in the world to possess its own fingerprinting technology. This technology has been crucial in various applications, including forensic science and judicial systems.

How has CCMB's universal primer technology aided in identifying animal products?

The universal primer technology developed by CCMB can identify the species of the source animal from any animal product, which is valuable for forensic and regulatory purposes.

What discovery did CCMB make regarding a specific heart disease mutation prevalent in the Indian population?

CCMB scientists discovered a specific heart disease mutation that is carried by approximately 6 crore (60 million) people within the Indian population.

What pioneering work in genetic engineering was achieved by CCMB with the development of a gene knockout mouse in India?

CCMB developed the first genetically engineered, gene knockout mouse in India, marking a significant advancement in genetic research capabilities within the country.

What reproductive technology was demonstrated by CCMB for the conservation of spotted deer?

CCMB demonstrated the first instance of artificial insemination in spotted deer, contributing to conservation efforts for this species.

What contribution did CCMB make to the development of anti-cancer drugs in India?

CCMB developed a systematic screening and validation program for anti-cancer drugs in India, advancing the research and development pipeline for cancer treatments.

How has CCMB utilized genomic studies to understand the Indian population and specific tribal groups?

Through genomic studies, CCMB has discovered the uniqueness of the Indian population and also investigated the origins of specific tribal groups, such as the Andaman tribes.

What commercially delivered diagnostic kit, based on recombinant DNA technology, has CCMB developed?

CCMB has commercially delivered a diagnostic kit based on recombinant DNA technology designed for the detection of pathogens that cause ophthalmic infections.

What improved rice strain was discovered by CCMB, and what problem does it address for farmers?

CCMB discovered an improved rice strain called Improved Samba Mahsuri, which is high-yielding and resistant to Bacterial Leaf Blight (BLB) disease, thus benefiting farmers in areas affected by this infection.

What functionality of microsatellites (simple sequence repeats) in non-coding DNA did CCMB discover?

CCMB discovered the functionality of microsatellites, also known as simple sequence repeats, within non-coding DNA, contributing to a deeper understanding of genetic structures.

What gene responsible for chronic pancreatitis was identified by CCMB in collaboration with the Asian Institute of Gastroenterology?

CCMB, in collaboration with the Asian Institute of Gastroenterology, discovered the gene CPA1, which is associated with causing chronic pancreatitis.

How have CCMB's students and scientists contributed to the growth of scientific institutions in India?

CCMB's students have formed an instrumental workforce in Indian academia, and its former scientists have been key in founding and leading numerous research and educational institutes across India.

What role did CCMB play in the establishment of the Centre for DNA Fingerprinting and Diagnostics (CDFD)?

Following the success of its DNA fingerprinting technology as accepted evidence in the Indian judicial system, CCMB was instrumental in the establishment of the Centre for DNA Fingerprinting and Diagnostics (CDFD) in Hyderabad.

How did CCMB contribute to the development of affordable vaccines through its incubation of Shantha Biotechnics?

In the 1990s, CCMB incubated India's first biotechnology company, Shantha Biotechnics Ltd., and supported them in developing a recombinant vaccine against Hepatitis-B that was made affordable for the Indian population.

In what ways has CCMB's DNA fingerprinting technology been applied to the Indian judicial system and criminal investigations?

CCMB's DNA fingerprinting technology has been crucial in solving numerous high-profile criminal cases, including murders, assassinations, and rapes, providing critical evidence for the Indian judicial system.

How did CCMB's DNA fingerprinting technology aid in identifying victims of the Singapore Airlines plane crash in 2000?

The DNA fingerprinting technology developed by CCMB was utilized to identify the victims of the Singapore Airlines plane crash that occurred in the year 2000.

What is the societal impact of CCMB's genetic disorder testing facilities?

CCMB's genetic disorder testing facilities offer services at nominal rates, benefiting patients not only from India but also from neighboring countries, thereby improving access to diagnostic healthcare.

How does CCMB contribute to training professionals in industries and government sectors?

CCMB provides skill development programs to train individuals for industries and also offers specialized training to forest and judiciary officials on understanding and effectively using DNA fingerprinting and universal primer technologies for justice.

What is CCMB attempting to develop in the area of sustainable food production?

CCMB is actively working on developing affordable techniques for producing lab-grown meat, exploring innovative approaches to food production.

How has CCMB supported the national response to the COVID-19 pandemic?

During the COVID-19 pandemic in India, CCMB served as one of the testing centers for patient samples in Telangana. It also aimed to contribute to the basic understanding of SARS-CoV2 biology to aid in the development of vaccines and drugs.

What international recognitions has CCMB received, such as being a Centre of Excellence?

CCMB has been recognized internationally as a Centre of Excellence by the UNESCO Global Network for Molecular and Cell Biology (MCBN) and designated as a South Centre for Excellence for Research and Training by the Third World Academy of Sciences (TWAS), Italy.

Name two prestigious awards that CCMB has received for its scientific and technological achievements.

CCMB has received prestigious awards such as the CSIR Technology Award (multiple times) and the FICCI Award for outstanding achievements in Science & Technology.

What are some of the significant national and international awards and fellowships held by CCMB scientists?

CCMB scientists have collectively earned numerous accolades, including one Padma Bhushan, four Padma Shri awards, three Infosys Prizes, eleven Shanti Swarup Bhatnagar awards, and fellowships from prestigious bodies like the JC Bose Foundation, Third World Academy of Sciences, Indian Academy of Sciences, National Academy of Sciences, and Indian National Science Academy.

How does CCMB facilitate access to its advanced instrumentation facilities?

CCMB makes its state-of-the-art instrumentation facilities available for use by external users at reasonable costs, promoting wider scientific research.

How can one reach the main campus of CCMB in Hyderabad?

The main campus of CCMB is conveniently located on the inner ring road of Hyderabad. It is accessible via city road transport buses and the Hyderabad metro, with a station at Habsiguda.

What is the significance of the image caption 'CCMB Hyderabad India'?

The image caption 'CCMB Hyderabad India' refers to a photograph of the Centre for Cellular and Molecular Biology located in Hyderabad, India, likely showcasing its physical infrastructure or campus.

What does the image caption 'Work on antimicrobial peptides at CCMB' refer to?

The image caption 'Work on antimicrobial peptides at CCMB' indicates that the associated image depicts research activities or findings related to antimicrobial peptides being conducted at the Centre for Cellular and Molecular Biology.

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About CCMB

The Institution

The Centre for Cellular and Molecular Biology (CCMB) is an autonomous, government-funded research establishment in Hyderabad, India. It operates under the Council of Scientific and Industrial Research (CSIR) and is recognized as a "Centre of Excellence" by UNESCO's Global Molecular and Cell Biology Network.

Motto & Affiliation

CCMB's guiding principle is "Dedicated to the Nation". As an autonomous body under the CSIR, it plays a pivotal role in India's scientific landscape, fostering advancements in life sciences.

Location & Campus

Situated in Hyderabad, Telangana, India, the main campus is located on Uppal Road. The urban campus spans 6 acres (24,000 m²), providing a dedicated space for research and development.

History

Genesis and Growth

CCMB was established on April 1, 1977, initially as a semi-autonomous centre. Its nucleus was formed from the Biochemistry Division of the Regional Research Laboratory (now IICT). Dr. P. M. Bhargava spearheaded its creation, following the CSIR's approval in 1976 to establish a centre focused on frontier areas of modern biology.

During 1981-82, CCMB achieved the status of a full-fledged national laboratory, complete with its own Executive Committee and Scientific Advisory Council. Recognizing the need for expansion, plans were made to relocate the centre to a more spacious campus.

Leadership Legacy

Former Directors

CCMB has been guided by distinguished leaders throughout its history. The following table outlines the tenure of its former directors:

Name	From	To
P. M. Bhargava	April 1977	February 1990
Sharat Chandra	March 1990	May 1992
Dorairajan Balasubramanian	May 1992	May 1998
Lalji Singh	May 1998	July 2009
Ch. Mohan Rao	July 2009	January 2016
Rakesh Kumar Mishra	May 2016	April 2021

Pioneering Research

Core Areas

CCMB's research endeavors are categorized into three primary streams: high-quality basic research in modern biology, research addressing societal needs, and application-oriented research for commercialization. Key areas include:

Evolution & Development
Gene Regulation in Prokaryotes and Eukaryotes
Host-Parasite Interactions
Membrane Biology
Protein Structure
Stem Cell Biology
Neurobiology
Bioinformatics
Functional Genomics
Ecology and Ecosystems

Innovation Hub (iHUB)

The Medical Biotechnology Complex, also known as the Innovation Hub (iHUB), facilitates molecular diagnostic tests for genetic disorders and wildlife forensics. It hosts the Atal Incubation Centre-CCMB (AIC-CCMB), supporting early-stage life science startups in areas like drug discovery, vaccine development, and diagnostics. It also houses a Meity Startup Hub initiative for big data in life sciences.

Specialized Annexes

LaCONES

The Laboratory for the Conservation of Endangered Species (LaCONES) is dedicated to conserving India's wildlife using modern biological techniques and assisted reproductive technologies. It collaborates with government departments to combat wildlife crime, identify animal product sources, and study stress in wild animals. It also houses the National Wildlife Genetic Resource Bank.

LaCONES has assisted in identifying the origins of smuggled animals and analyzing bird hits for aerospace safety. They have supported the Nehru Zoological Park in protecting mouse deer and facilitating their phased release into the Amrabad Tiger Reserve.

Medical Biotechnology Complex

This complex focuses on molecular diagnostics for numerous genetic disorders and wildlife forensics. It also serves as the Atal Incubation Centre (AIC-CCMB), fostering startups in various life science domains. The initiative is supported by NITI Aayog and the Atal Innovation Mission.

AIC-CCMB supports startups in drug discovery, vaccine development, diagnostics, and nanomaterial development. It also hosts a Meity Startup Hub to incubate ventures focused on big data in the life sciences and healthcare sectors.

Global Partnerships

International Reach

CCMB actively engages in international collaborations, receiving funding and participating in joint projects with leading global institutions. These include:

National Institutes of Health (NIH), Harvard Medical School, Massachusetts Institute of Technology (USA)
Imperial Cancer Research Fund, Cambridge University (UK)
India-Japan Science Council, University of Ryukyus (Japan)
Centre Nationale de la Recherche Scientifique (CNRS), Pasteur Institute (France)
Volkswagen Foundation (Germany)

National Network

Domestically, CCMB collaborates with premier research institutes and universities across India, fostering a robust scientific ecosystem. Notable national partners include:

Tata Institute of Fundamental Research (TIFR)
Institute for Stem Cell Science and Regenerative Medicine (InStem)
ICAR-Indian Institute of Rice Research
University of Hyderabad
CSIR-Institute of Genomics and Integrative Biology (IGIB)
ICAR-National Research Centre on Meat

Technological Milestones

Key Innovations

CCMB has achieved significant technological breakthroughs, positioning India at the forefront of biological sciences:

Developed India's first DNA Fingerprinting Technology, enabling its use in the judicial system.
Created universal primer technology for identifying animal species from products.
Discovered a heart disease mutation prevalent in the Indian population.
Developed India's first genetically engineered gene knockout mouse.
Successfully demonstrated artificial insemination in spotted deer.
Established a systematic screening program for anti-cancer drugs.
Uncovered unique insights into Indian population genomics and Andaman tribes' origins.
Commercialized recombinant DNA technology-based diagnostic kits for ophthalmic infections.
Developed pest-resistant Samba Mahsuri rice strains.
Discovered native bacteria (Indibacter alkaliphilus) for industrial biotechnology.
Identified the functionality of microsatellites in non-coding DNA.
Discovered the CPA1 gene linked to chronic pancreatitis.

Societal Impact

Nurturing Talent and Institutions

CCMB has been instrumental in shaping India's scientific workforce and institutions:

Its PhD alumni form a significant part of Indian academia and the life science industry.
CCMB scientists have founded and led numerous research and educational institutes, including the Centre for DNA Fingerprinting and Diagnostics (CDFD), InStem, IISERs, and LV Prasad Eye Institute.
CCMB incubated Shantha Biotechnics Ltd., India's first biotech company, aiding in the development of an affordable Hepatitis-B vaccine.

Justice and Public Welfare

The institute's technologies have had profound societal implications:

DNA fingerprinting has been crucial in solving high-profile criminal cases and identifying victims of disasters (e.g., Singapore Airlines plane crash).
Genetic disorder testing services are provided at nominal rates to benefit patients in India and neighboring countries.
The elite rice varieties project aims to support farmers with improved crop yields and disease resistance.
CCMB actively trains forest and judiciary officials in DNA fingerprinting technologies.
The institute played a vital role during the COVID-19 pandemic as a testing center and in researching SARS-CoV-2 biology.

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References

The worst luck in the world? â Wellcome Trust Sanger Institute

CCMB implements artificial insemination in deer â India â DNA

A full list of references for this article are available at the Centre for Cellular and Molecular Biology Wikipedia page

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Disclaimer

Important Notice

This page was generated by an Artificial Intelligence and is intended for informational and educational purposes only. The content is derived from publicly available data from Wikipedia and may not be entirely accurate, complete, or up-to-date.

This is not professional scientific advice. The information provided on this website is not a substitute for professional consultation regarding cellular and molecular biology, biotechnology, or related scientific fields. Always refer to official documentation and consult with qualified experts for specific research or application needs. Never disregard professional advice because of information found on this website.

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CCMB: Illuminating Life's Molecules

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About CCMB ℹ️

🏛️ The Institution

📜 Motto & Affiliation

📍 Location & Campus

History ⏳

🚀 Genesis and Growth

Leadership Legacy 🧑‍⚖️

📜 Former Directors

Pioneering Research 🧪

🔬 Core Areas

💡 Innovation Hub (iHUB)

Specialized Annexes 🏢

🐾 LaCONES

🧬 Medical Biotechnology Complex

Global Partnerships 🤝

🌍 International Reach

🇮🇳 National Network

Technological Milestones ✨

🏆 Key Innovations

Societal Impact 🌍

🎓 Nurturing Talent and Institutions

⚖️ Justice and Public Welfare

Teacher's Corner 🧑‍🏫

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📜 References

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Disclaimer ⚠️

📜 Important Notice

Dive in with Flashcard Learning!

About CCMB

The Institution

Motto & Affiliation

Location & Campus

History

Genesis and Growth

Leadership Legacy

Former Directors

Pioneering Research

Core Areas

Innovation Hub (iHUB)

Specialized Annexes

LaCONES

Medical Biotechnology Complex

Global Partnerships

International Reach

National Network

Technological Milestones

Key Innovations

Societal Impact

Nurturing Talent and Institutions

Justice and Public Welfare

Teacher's Corner

True or False?

Test Your Knowledge!

Gamer's Corner

Discover other topics to study!

References

Feedback & Support

Disclaimer

Important Notice