What is The New England Journal of Medicine (NEJM)?

The New England Journal of Medicine (NEJM) is a weekly peer-reviewed medical journal published by the Massachusetts Medical Society. It is recognized as one of the most prestigious and influential medical journals globally.

When was The New England Journal of Medicine founded, and by whom?

The New England Journal of Medicine was founded in 1812 by Boston physician John Collins Warren, along with James Jackson, who submitted a prospectus to establish it as a medical and philosophical journal.

What was the initial publication frequency of the journal?

Upon its founding in January 1812, the journal, then named the New England Journal of Medicine and Surgery and the Collateral Branches of Medical Science, was published quarterly.

How did the journal evolve through mergers and name changes?

The journal evolved through several stages: it began as the New England Journal of Medicine and Surgery, merged with the Boston Medical Intelligencer in 1828 to become the Boston Medical and Surgical Journal (shifting to weekly publication), and was finally renamed The New England Journal of Medicine in 1928 after being purchased by the Massachusetts Medical Society.

Who is the current editor-in-chief of The New England Journal of Medicine?

The current editor-in-chief of The New England Journal of Medicine is Eric Rubin.

What is the primary discipline covered by The New England Journal of Medicine?

The primary discipline covered by The New England Journal of Medicine is Medicine.

In what language is The New England Journal of Medicine published?

The New England Journal of Medicine is published in English.

Who is the publisher of The New England Journal of Medicine?

The New England Journal of Medicine is published by the Massachusetts Medical Society in the United States.

What is the publication frequency of The New England Journal of Medicine?

The New England Journal of Medicine is published weekly.

What is the open access policy for NEJM articles?

NEJM offers delayed open access, making articles freely available six months after publication. Additionally, articles of global and public health importance are made freely available immediately upon publication on NEJM.org.

Does NEJM charge authors for article submission or publication?

No, NEJM does not charge authors any submission or publication fees.

What does the NEJM logo symbolize?

The NEJM logo depicts the Rod of Asclepius crossed over a quill pen. The dates incorporated into the logo represent the founding years of its predecessor publications: 1812, 1823, 1828, and 1928.

What significant medical report was published in NEJM in November 1846?

In November 1846, the journal published Henry Jacob Bigelow's report on the first public demonstration of inhaled ether as a generalized anesthetic, which revolutionized surgical procedures by rendering patients insensible to pain.

What discovery concerning blood components was detailed in a 1906 article by James Homer Wright?

In June 1906, James Homer Wright published an article describing his study of bone marrow, which included detailed observations of what are now known as megakaryocytes and platelets.

What revolutionary neurological concept was presented in a lecture published in NEJM in October 1872?

In October 1872, a lecture by Charles-Édouard Brown-Séquard was published, proposing the concept that one cerebral hemisphere could influence both sides of the body, and he later described what is now known as the Brown-Séquard syndrome.

What breakthrough in treating childhood leukemia was reported by Sidney Farber in 1948?

In June 1948, Sidney Farber reported promising results in treating acute lymphoblastic leukemia in children using aminopterin, a folic acid inhibitor, leading to temporary remissions.

What innovation in cardiac resuscitation was published by Paul Zoll in 1952?

In November 1952, cardiologist Paul Zoll published a report on the successful use of an external electric pacemaker to revive the heart from ventricular standstill, a significant advancement for patients experiencing cardiac arrest.

What new endoscopic procedure for cancer risk reduction was introduced in a 1973 NEJM article?

In February 1973, the journal published the first report on polyp removal using a colonoscope, introducing a procedure that could reduce cancer risk by removing polyps during endoscopic screening.

What controversial claim about opioid addiction was published in NEJM in 1980?

A letter published in NEJM in 1980 claimed that addiction due to the use of narcotics was rare. This claim was later heavily cited and used to promote opioid use, contributing to the U.S. opioid crisis.

What significant disease was described in landmark articles in NEJM in December 1981?

In December 1981, two landmark articles published in NEJM described the clinical course of four patients with the disease that would eventually be known as AIDS (Acquired Immunodeficiency Syndrome).

What targeted therapy for chronic myelogenous leukemia was reported in NEJM in April 2001?

In April 2001, Brian Druker and colleagues reported on the efficacy of a specific inhibitor of the BCR-ABL tyrosine kinase for treating chronic myelogenous leukemia, initiating an era of targeted cancer therapies.

What unprecedented editorial stance did NEJM take regarding the COVID-19 pandemic in October 2020?

In October 2020, NEJM published an editorial signed by all its editors condemning the Trump administration's handling of the COVID-19 pandemic as 'dangerously incompetent,' marking a rare instance of the journal taking a public political stance.

What comparison between psilocybin and an SSRI for depression treatment was published in April 2021?

In April 2021, NEJM published a study by Robin Carhart-Harris et al. that compared the psychedelic drug psilocybin with the SSRI escitalopram for treating major depressive disorder, finding no significant difference in antidepressant effects after six weeks.

When did NEJM first launch its website and begin electronic publication?

NEJM announced its new website and began electronic publication on April 25, 1996, initially publishing abstracts of research articles and the full text of editorials, cases, and letters.

What online features has NEJM developed to enhance its digital presence?

NEJM has developed features such as 'Videos in Clinical Medicine' for teaching procedures, 'Interactive Medical Cases' for simulating clinical encounters, and the 'NEJM Archive' for accessing its entire collection of published material.

How has NEJM's influence in the medical field been recognized?

NEJM's influence is recognized through awards like the George Polk Award in 1977 and its consistently high impact factor, often ranking first among general and internal medicine journals, demonstrating its significant prestige and reach.

What criticism has been raised regarding the influence and content of NEJM?

Theodore Dalrymple, in his book 'False Positive,' criticized NEJM, suggesting that some articles presented conclusions not supported by evidence or ignored contradictory information, questioning the journal's influence.

What is NEJM Evidence, and when was it established?

NEJM Evidence is a monthly digital sub-journal launched in 2022 by NEJM, dedicated to publishing original research, clinical trials, and decision-making in medicine.

What is the Ingelfinger rule, and what is its purpose?

The Ingelfinger rule is a policy maintained by NEJM that requires articles submitted for publication not to have been previously published or released elsewhere. Its purpose is to ensure that research undergoes peer review before being widely disseminated to the public or profession.

Are there exceptions to the Ingelfinger rule?

Yes, exceptions to the Ingelfinger rule exist, particularly when the immediate implications for public health warrant a prepublication release of research conclusions.

Who first articulated the Ingelfinger rule?

The Ingelfinger rule was first described in a 1969 editorial titled 'Definition of Sole Contribution' by Franz Ingelfinger, who was the editor-in-chief of NEJM at that time.

What was the Vioxx correction controversy involving NEJM?

The controversy centered on a 2000 NEJM study about the drug Vioxx, which noted increased myocardial infarction risk. Concerns about data interpretation and undisclosed adverse events led to an 'Expression of Concern' by NEJM in 2005 after it was revealed authors had prior knowledge of additional heart attacks.

What financial relationship between Merck and NEJM was highlighted during the Vioxx controversy?

During the period between the Vioxx study's publication and NEJM's expression of concern, Merck reportedly paid the journal up to US$836,000 for article reprints, which were used for promotional purposes.

What is the impact factor of NEJM as reported for 2024?

As of 2024, The New England Journal of Medicine has an impact factor of 78.5.

How does NEJM rank among 'Medicine, General & Internal' journals based on its 2024 impact factor?

Based on its 2024 impact factor of 78.5, NEJM ranked second out of 168 journals in the 'Medicine, General & Internal' category.

What is the historical significance of the name 'Boston Medical and Surgical Journal'?

The 'Boston Medical and Surgical Journal' was the name adopted in 1828 after the merger of two earlier publications, marking a shift to weekly publication and serving as a predecessor to the current NEJM.

What does the date '1812' signify in the context of NEJM's history?

The year 1812 signifies the founding of the journal's earliest predecessor, the 'New England Journal of Medicine and Surgery and Collateral Branches of Science'.

What does the date '1928' signify in the context of NEJM's history?

The year 1928 signifies the official renaming of the journal to 'The New England Journal of Medicine'.

What types of content are available on the NEJM website beyond research articles?

The NEJM website offers full-text access to editorials, cases, and letters to the editor, as well as features like 'Videos in Clinical Medicine,' 'Interactive Medical Cases,' and the 'NEJM Archive'.

What is the purpose of the 'Videos in Clinical Medicine' feature?

The 'Videos in Clinical Medicine' feature provides peer-reviewed educational videos designed to teach skilled techniques and specialized physical examinations required in medical practice.

What is the 'Interactive Medical Cases' feature on the NEJM website?

'Interactive Medical Cases' simulates a clinical encounter by presenting patient history, examination results, and diagnostic tests, accompanied by multiple-choice questions to test the user's knowledge.

What recognition did NEJM receive from the George Polk Awards?

The George Polk Awards recognized NEJM in 1977, stating that the award provided the journal with its first significant mainstream visibility, paving the way for its subsequent prestige and attention.

What is the CODEN identifier for The New England Journal of Medicine?

The CODEN identifier for The New England Journal of Medicine is NEJMAG.

What are the print and online ISSNs for The New England Journal of Medicine?

The print ISSN for The New England Journal of Medicine is 0028-4793, and the web ISSN is 1533-4406.

What is the historical significance of the Massachusetts Medical Society's purchase of the journal?

The Massachusetts Medical Society purchased the journal in 1921 for US$1, ensuring its continued publication and eventual renaming to The New England Journal of Medicine in 1928, solidifying its institutional backing.

What is the stated goal of the Ingelfinger rule regarding research dissemination?

The Ingelfinger rule aims to protect the newsworthiness of research by ensuring it undergoes peer review by the journal before being promoted to the public or the medical profession.

What was the first article published in the journal's current format in 1928?

The article 'The Journal's New Look' published in February 1928 marked the first use of the present name, The New England Journal of Medicine, and discussed the journal's evolving presentation.

What is the NEJM's policy on making research articles available to authors' funders?

NEJM works with authors to ensure they can meet their funders' open access mandates, providing necessary documentation or manuscript versions for public access, especially for research supported by organizations like the NIH or Plan S funders.

What is the frequency of publication for the specialty journal NEJM Evidence?

NEJM Evidence, a specialty journal established by NEJM, is published monthly.

What specific type of therapy for chronic myelogenous leukemia was reported in the 2001 NEJM article?

The 2001 NEJM article reported on a targeted therapy using an inhibitor of the BCR-ABL tyrosine kinase, which specifically targets the molecular abnormality causing chronic myelogenous leukemia.

What is the significance of the 2021 NEJM study comparing psilocybin and escitalopram?

This study was significant as it was the first time a psychedelic drug (psilocybin) and a leading SSRI antidepressant (escitalopram) were directly compared in the treatment of depression, showing comparable effectiveness.

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Journal Overview

Scholarly Publication

The New England Journal of Medicine (NEJM) is a weekly peer-reviewed medical journal published by the Massachusetts Medical Society. Established in 1812, it is recognized as one of the most prestigious and influential medical journals globally.

Academic Standing

With a 2024 impact factor of 78.5, NEJM ranks second among 168 journals in the "Medicine, General & Internal" category. This high citation rate underscores its significant influence in disseminating medical research and clinical findings.

Global Reach

The journal publishes original research, reviews, and commentaries, making its content accessible to a worldwide audience of healthcare professionals, researchers, and policymakers. Its online platform extends its reach significantly.

Historical Trajectory

Foundational Years

The journal's origins trace back to September 1811, with a prospectus for the New England Journal of Medicine and Surgery and Collateral Branches of Science. The first issue appeared in January 1812, initially published quarterly.

1812: First issue of New England Journal of Medicine and Surgery and the Collateral Branches of Medical Science.
1828: Merged with Boston Medical Intelligencer to become the weekly Boston Medical and Surgical Journal.
1928: Renamed to The New England Journal of Medicine, marking a significant rebranding.

Society Ownership

In 1921, the Massachusetts Medical Society acquired the journal for one US dollar. This transition solidified its institutional backing and commitment to advancing medical knowledge.

Digital Transformation

NEJM embraced digital publication early, launching its website in 1996. By 1998, it offered full-text access to articles from 1993 onwards, pioneering online access to medical literature.

1996: Announcement of a new website publishing abstracts and full text of editorials, cases, and letters.
1997: Introduction of prepublication releases online.
Ongoing: Development of features like Videos in Clinical Medicine, Interactive Medical Cases, and podcasts.

Influence and Recognition

Prestigious Standing

The journal's influence is recognized by accolades such as the George Polk Award in 1977, highlighting its growing prestige. Its consistently high impact factor places it at the forefront of medical publications.

Research Dissemination

NEJM is instrumental in disseminating groundbreaking research. Its articles often set standards and influence clinical practice, making it a critical resource for medical professionals worldwide.

Critical Perspectives

While highly influential, the journal's impact has also drawn criticism. Some analyses suggest that certain conclusions in published articles may not be fully supported by the evidence presented, or that the journal's influence may be disproportionate.

Landmark Publications

Anesthesia Breakthrough

In 1846, Henry Jacob Bigelow reported on the first public demonstration of ether anesthesia, revolutionizing surgical procedures by enabling pain management during operations.

Hematology Insights

James Homer Wright's 1906 article described bone marrow components, including megakaryocytes and platelets, contributing significantly to the understanding of hematopoiesis.

Neurology and Physiology

Charles-Édouard Brown-Séquard's 1872 lecture proposed the concept of hemispheric influence on both sides of the body, laying groundwork for understanding lateralization and neurological syndromes.

Cancer Treatment Advances

Sidney Farber's 1948 report on temporary remissions in childhood leukemia using aminopterin marked an early success in chemotherapy. Brian Druker's 2001 article on BCR-ABL tyrosine kinase inhibitors heralded the era of targeted cancer therapy.

Infectious Disease Reports

In December 1981, NEJM published early clinical descriptions of patients with what would become known as AIDS, providing critical initial documentation of the emerging epidemic.

Psychedelic Research

A 2021 study by Robin Carhart-Harris et al. compared psilocybin with escitalopram for depression, finding comparable antidepressant effects and opening new avenues for psychedelic research in mental health.

Key Policies

Ingelfinger Rule

The Ingelfinger rule mandates that articles published in NEJM must not have been previously published or released elsewhere. This policy aims to preserve the newsworthiness of findings and ensure peer review precedes public dissemination.

First described by editor Franz Ingelfinger in 1969, the rule is intended to maintain the integrity of research reporting. Exceptions are recognized, particularly when immediate public health implications warrant prepublication release of findings.

Open Access

NEJM provides immediate free access to articles deemed of global and public health importance on NEJM.org. It also partners with initiatives like Research4Life to grant access to low-income countries. For articles submitted after February 1, 2024, authors receive an Author Accepted Manuscript PDF for repository deposit.

Notable Controversies

Vioxx Publication Issues

In the early 2000s, NEJM faced scrutiny over the publication of research on the drug Vioxx. A 2000 study noted increased myocardial infarctions, but concerns were raised about the authors' disclosure of adverse events and potential conflicts of interest with Merck.

Despite early concerns raised in 2001, NEJM published an "Expression of Concern" in 2005 after discovering authors had knowledge of additional myocardial infarctions prior to publication. The journal's response and financial ties to Merck for reprints were criticized by other medical publications.

Political Editorial

In October 2020, NEJM published an editorial signed by all editors condemning the Trump administration's handling of the COVID-19 pandemic. This marked a rare instance of the journal taking a public stance on political matters.

Opioid Crisis Citation

A 1980 letter published in NEJM, claiming addiction from opioid use was rare, was later described by the journal as "heavily and uncritically cited." This publication was reportedly used by pharmaceutical companies to promote opioid use, contributing to the ongoing addiction crisis.

Editorial Leadership

Past and Present Editors

The journal has been guided by distinguished editors throughout its history, shaping its content and editorial direction. The current editor-in-chief is Eric Rubin.

Walter Prentice Bowers (1921–1937)
Robert Nason Nye (1937–1947)
Joseph Garland (1947–1967)
Franz J. Ingelfinger (1967–1977)
Arnold S. Relman (1977–1991)
Jerome P. Kassirer (1991–1999)
Marcia Angell (1999–2000)
Jeffrey M. Drazen (2000–2019)
Eric Rubin (2019–present)

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References

Boston Patriot. September 28, 1811

A full list of references for this article are available at the The New England Journal of Medicine Wikipedia page

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Important Notice

This page was generated by an Artificial Intelligence and is intended for informational and educational purposes only. The content is based on a snapshot of publicly available data from Wikipedia and may not be entirely accurate, complete, or up-to-date.

This is not medical advice. The information provided on this website is not a substitute for professional medical consultation, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.

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The Journal of Medical Authority

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Journal Overview ℹ️

📚 Scholarly Publication

📊 Academic Standing

🌐 Global Reach

Historical Trajectory 📅

📜 Foundational Years

🏛️ Society Ownership

💻 Digital Transformation

Influence and Recognition 📈

🏆 Prestigious Standing

🔬 Research Dissemination

🤔 Critical Perspectives

Landmark Publications 💡

⚗️ Anesthesia Breakthrough

🩸 Hematology Insights

🧠 Neurology and Physiology

💊 Cancer Treatment Advances

🦠 Infectious Disease Reports

🌿 Psychedelic Research

Key Policies ⚖️

🔒 Ingelfinger Rule

🔓 Open Access

Notable Controversies ⚠️

⚖️ Vioxx Publication Issues

🗣️ Political Editorial

❓ Opioid Crisis Citation

Editorial Leadership 🧑‍💼

📜 Past and Present Editors

Teacher's Corner 🧑‍🏫

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📜 Important Notice

Dive in with Flashcard Learning!

Journal Overview

Scholarly Publication

Academic Standing

Global Reach

Historical Trajectory

Foundational Years

Society Ownership

Digital Transformation

Influence and Recognition

Prestigious Standing

Research Dissemination

Critical Perspectives

Landmark Publications

Anesthesia Breakthrough

Hematology Insights

Neurology and Physiology

Cancer Treatment Advances

Infectious Disease Reports

Psychedelic Research

Key Policies

Ingelfinger Rule

Open Access

Notable Controversies

Vioxx Publication Issues

Political Editorial

Opioid Crisis Citation

Editorial Leadership

Past and Present Editors

Teacher's Corner

True or False?

Test Your Knowledge!

Gamer's Corner

Discover other topics to study!

References

Feedback & Support

Disclaimer

Important Notice